全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Gema Alcarraz-Vizán , Carlos Castaño , Montse Visa ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (15), pp.2827-2838Springer
摘要:BACE2 (β-site APP-cleaving enzyme 2) is a protease expressed in the brain, but also in the pancreas, where it seems to play a physiological role. Amyloidogenic diseases, including Alzheimer’s disease and type 2 diabetes (T2D), share the accumulation of abnormally folded and ...
作者:Silvia Peppicelli , Elena Andreucci , Jessica Ruzzolini ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (15), pp.2761-2771Springer
摘要:Although surgical excision, chemo-, and radio-therapy are clearly advanced, tumors may relapse due to cells of the so-called “minimal residual disease”. Indeed, small clusters of tumor cells persist in host tissues after treatment of the primary tumor elaborating strategies ...
作者:Vladimir N. Uversky
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (17), pp.3065-3067Springer
摘要:The concept of protein intrinsic disorder persistently penetrates into all areas of modern protein science. It cannot be ignored anymore, and cannot be shrugged off, as it represents a vital feature (or, more correctly, a broad spectrum of important features), which, when added t...
作者:Julhash U. Kazi , Rohit A. Chougule , Tianfeng Li ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (14), pp.2679-2688Springer
摘要:The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for...
作者:Serge M. Candéias , Justyna Mika , Paul Finnon ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (23), pp.4339-4351Springer
摘要:While the biological effects of high-dose-ionizing radiation on human health are well characterized, the consequences of low-dose radiation exposure remain poorly defined, even though they are of major importance for radiological protection. Lymphocytes are very radiosensiti...
作者:Adnan S. Syed , Alfredo Sansone , Thomas Hassenklöver ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (9), pp.1711-1719Springer
摘要:All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomero...
作者:Junjun Liu , Chuanmao Zhang
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (12), pp.2127-2134Springer
摘要:PLK1 regulates almost every aspect of mitotic events, including mitotic entry, spindle assembly, chromosome alignment, sister chromatid segregation, metaphase-anaphase transition, cytokinesis, etc. In regulating the chromosome alignment and sister chromatid segregation, PLK1 has ...
作者:Nikita Minhas , Meilang Xue , Christopher J. Jackson
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (10), pp.1895-1906Springer
摘要:Activated protein C (APC) is a natural anticoagulant with strong anti-inflammatory, anti-apoptotic, and barrier stabilizing properties. These cytoprotective properties of APC are thought to be exerted through its pathway involving the binding of APC to endothelial protein C ...
作者:Ho-Chang Jeong , Seung-Ju Cho , Mi-Ok Lee ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (14), pp.2601-2611Springer
摘要:Despite the recent promising results of clinical trials using human pluripotent stem cell (hPSC)-based cell therapies for age-related macular degeneration (AMD), the risk of teratoma formation resulting from residual undifferentiated hPSCs remains a serious and critical hurdle fo...
作者:Ya-Long Wang , Claire Xi Zhang
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (16), pp.2917-2927Springer
摘要:In chemical synapses, action potentials evoke synaptic vesicle fusion with the presynaptic membrane at the active zone to release neurotransmitter. Synaptic vesicle endocytosis (SVE) then follows exocytosis to recapture vesicle proteins and lipid components for recycling and the ...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×