全部文献期刊会议图书|学者科研项目
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作者:Federica Finetti , Irene Schiavo , Jasmine Ercoli ...
来源:[J].Cellular Signalling(IF 4.304), 2020
摘要:Abstract(#br)Cerebral cavernous malformation (CCM) is a cerebrovascular disorder of proven genetic origin characterized by abnormally dilated and leaky capillaries occurring mainly in the central nervous system, with a prevalence of 0.3–0.5% in the general population. Geneti...
作者:Li Cheng , Baoming Wu , Lei Zhang ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.65
摘要:Abstract(#br)Background(#br)Although gankyrin has been identified as a vital regulator of tumorigenesis, its role and regulatory mechanism in osteosarcoma (OS) remain unclear.(#br)Methods(#br)QRT-PCR, western blot and IHC staining were conducted to detect the expression of g...
作者:Paul Dent , Laurence Booth , Andrew Poklepovic ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.68
摘要:Abstract(#br)The ERBB1/2/4 inhibitor neratinib causes plasma membrane-associated K-RAS to mislocalize into intracellular vesicles; this effect is enhanced by HDAC inhibitors and the combination of [neratinib + sodium valproate] is now a phase I trial ( NCT03919292 ). The pre...
作者:Matthew A. Held , Emily Greenfest-Allen , Su Su ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.69
摘要:Abstract(#br)The formation of erythroid progenitor cells depends sharply upon erythropoietin (EPO), its cell surface receptor (erythropoietin receptor, EPOR), and Janus kinase 2 (JAK2). Clinically, recombinant human EPO (rhEPO) additionally is an important anti-anemia agent ...
作者:Jiao Ye , Liang Zhong , Ling Xiong ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.69
摘要:Abstract(#br)The promyelocytic leukemia-retinoic acid receptor α (PML/RARα) is hypothesized to play a vital role in the pathogenesis of acute promyelocytic leukemia (APL). A previous study has demonstrated that PML/RARα is cleaved by neutrophil elastase (NE) in early myeloid...
作者:Daniel P. Potaczek , Sarah Miethe , Viktoria Schindler ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.69
摘要:Abstract(#br)The term (bronchial) asthma describes a disorder syndrome that comprises several disease phenotypes, all characterized by chronic inflammation in the bronchial epithelium, with a variety of subsequent functional consequences. Thus, the epithelium in the conducting ai...
作者:Matthias Krämer , Philipp Markart , Fotis Drakopanagiotakis ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.65
摘要:Abstract(#br)Pirfenidone (PFD) is an orally available synthetic drug which has been approved for the treatment of idiopathic pulmonary fibrosis. In addition to its anti-fibrotic properties, PFD also exerts anti-tumor effects in cancer models by inducing alterations in the tu...
作者:Xingkang Jiang , Shanqi Guo , Yangyi Zhang ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.65
摘要:Abstract(#br)Docetaxel resistance remains one of the main problems in clinical treatment of metastatic prostate cancer (PCa). Previous studies identified differently expressed lncRNAs in docetaxel-resistant PCa cell lines, while the potential mechanisms were still unknown. I...
作者:Karla Rubio , Rafael Castillo-Negrete , Guillermo Barreto
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.70
摘要:Abstract(#br)Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. On the other hand, idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease showing a prevalence of 20 new cases per 100,000 persons per year. Despite differences i...
作者:Han-Yu Li , Hong-Chun He , Jing-Feng Song ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.66
摘要:Abstract(#br)Background(#br)Severe acute pancreatitis (SAP) is associated with high morbidity and mortality. Bone marrow mesenchymal stem cells (BMSCs) have shown obvious protective effect on SAP. However, little is known about the underlying mechanism. The objective of this...

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