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作者:Winton D J , Gooderham N J , Boobis A R ...
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (24), pp.7992-6PubMed
摘要:The ability of three model carcinogens, 1,2-dimethylhydrazine, dimethylnitrosamine, and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, to induce mutation in a novel in vivo assay in mouse intestine has been examined. The assay is based on mutations at the Dlb-1 locus which determ...
作者:Ali-Osman F , Stein D E , Renwick A
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (21), pp.6976-80PubMed
摘要:gamma-L-glutamyl-L-cysteinylglycine (GSH) has been shown to inactivate 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and quench DNA crosslink precursors of BCNU. Because of the central role of 2-chloroethyl-nitrosoureas in brain tumor chemotherapy, we investigated the intracellular...
作者:Qiuping Zhang , Jei Xiong , Youxin Jin ...
来源:[J].Cancer research(IF 8.65), 2004, Vol.64 (20), pp.7579-87PubMed
摘要:We investigated CD4 and CD8 double-positive thymocytes, CD4(+) T cells from typical patients with T-cell lineage acute lymphocytic leukemia (T-ALL) and T cell lineage chronic lymphocytic leukemia (T-CLL), and MOLT4 T cells in terms of CC chemokine ligand 25 (CCL25) functions of i...
作者:Biasi G , Mazzocchi M , Facchinetti A ...
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (17 Suppl), pp.5703S-5706SPubMed
摘要:The role of CD4+ cells in the immune response to Moloney murine sarcoma/leukemia virus complex was studied in adult mice undergoing long-term CD4+ cell functional depletion by treatment with anti-CD4 H129.19 monoclonal antibody (immunoglobulin G2a, kappa). Adult mice given inject...
作者:Kim S K , Fan Y , Papadimitrakopoulou V ...
来源:[J].Cancer research(IF 8.65), 1996, Vol.56 (11), pp.2519-21PubMed
摘要:DPC4, a candidate tumor suppressor gene, was identified recently at chromosome 18q21.1. Frequent homozygous deletion or mutations of the gene were observed in pancreatic carcinomas. To investigate the role of this gene in head and neck squamous cell carcinomas (HNSCCs), we examin...
作者:Zhang X Y , Supakar P C , Wu K Z ...
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (21), pp.6865-9PubMed
摘要:The expression of the human c-myc protooncogene is subject to many levels and types of control. Evidence suggests that regulation of the expression of this gene involves elements within the gene as well as those upstream from the gene. We show that a ubiquitous mammalian sequence...
作者:Reubi J C , Kvols L K , Waser B ...
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (18), pp.5969-77PubMed
摘要:Somatostatin (SS) receptor status was investigated in the tumor tissues from 62 patients with carcinoid tumors and 15 patients with islet cell carcinomas using receptor autoradiography techniques with two different iodinated somatostatin analogues as radioligands, a [Leu8, DTrp22...
作者:Chan W S , Marshall J F , Svensen R ...
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (15), pp.4533-8PubMed
摘要:Aluminum sulfonated phthalocyanine has potential as a suitable photosensitizer for use in the photodynamic therapy of cancer. In the present study, cellular uptake and retention of the individual mono-, di-, tri-, and tetrasulfonated derivatives (AlS1-4Pc) were examined in tissue...
作者:Munson G P , Woloschak G E
来源:[J].Cancer research(IF 8.65), 1990, Vol.50 (16), pp.5045-8PubMed
摘要:Experiments were designed to examine in vivo changes in total transcription and in the expression of the c-fos gene following whole-body exposure of mice to JANUS fission-spectrum neutrons. Radiation repair-deficient (wst/wst) and -proficient (wst/., C57BL/6 x C3H F1) mice were e...

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