全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Kim Sung Soo , Ruiz Victoria E , Carroll Jaqueline D ...
来源:[J].Cancer Letters, 2010, Vol.305 (2), pp.228-38PubMed
摘要:Chronic gastric infection by the gram-negative bacterium Helicobacter pylori is strongly associated with the development of distal gastric carcinoma and gastric mucosal lymphoma in humans. Eradication of H. pylori with combination antibiotic therapy cures most cases of gastric ly...
作者:Fried Bernard , Reddy Aditya , Mayer David
来源:[J].Cancer Letters, 2010, Vol.305 (2), pp.239-49PubMed
摘要:This review examines the salient literature on selected helminths involved in carcinogenicity in humans and updates information in an earlier review on cancer and helminths by Mayer and Fried (2007, Advances in Parasitology 65, 239-296). The earlier review was concerned with vari...
作者:Niller Hans Helmut , Wolf Hans , Minarovits Janos
来源:[J].Cancer Letters, 2010, Vol.305 (2), pp.200-17PubMed
摘要:It is well documented that viral genomes either inserted into the cellular DNA or co-replicating with it in episomal form can be lost from neoplastic cells. Therefore, "hit and run"-mechanisms have been a topic of longstanding interest in tumor virology. The basic idea is that th...
作者:Mehta Pramod P , Kung Pei-Pei , Yamazaki Shinji ...
来源:[J].Cancer Letters, 2010, Vol.300 (1), pp.30-9PubMed
摘要:Hsp90 is required for conformational maturation and stability of numerous key signaling proteins (clients) involved in cell proliferation and transformation. Here we describe two novel Hsp90 inhibitors, PF-4470296 and PF-3823863, demonstrate a differential sensitivity in B-Raf mu...
作者:Daskalos Alexandros , Logotheti Stella , Markopoulou Soultana ...
来源:[J].Cancer Letters, 2010, Vol.300 (1), pp.79-86PubMed
摘要:p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the anti-apoptotic ΔΝp73 isoforms respectively. In this study, we investigated the DNA methylation status of both promoters as a means of ep...
作者:Ahmad Nihal , Kumar Raj
来源:[J].Cancer Letters, 2010, Vol.300 (1), pp.1-9PubMed
摘要:The steroid hormone receptors (SHRs) are ligand-dependent intracellular transcription factors that are known to influence the development and growth of many human cancers. SHRs pass signals from a steroid/hormone to the target genes by interacting with specific response element D...
作者:Hartmannsberger Diana , Mack Brigitte , Eggert Carola ...
来源:[J].Cancer Letters, 2010, Vol.300 (1), pp.20-9PubMed
摘要:Transketolase-like protein 1 (TKTL1) is a member of the family of transketolase enzymes of which the founder member transketolase (TKT) is known to play a central role in the non-oxidative part of the pentose phosphate pathway. According to several publications TKTL1 is the only ...
作者:Zimmerman Amy L , Wu Shiyong
来源:[J].Cancer Letters, 2010, Vol.300 (1), pp.10-9PubMed
摘要:MicroRNAs regulate self-renewal, differentiation, and division of cells via post-transcriptional gene silencing. Aberrant microRNA levels, specifically an overall downregulation, are present in many cancers, as compared to their normal tissue counterparts. Therefore, a potential ...
作者:Lin Zhen , Flemington Erik K
来源:[J].Cancer Letters, 2010, Vol.305 (2), pp.186-99PubMed
摘要:Tumor viruses are a class of pathogens with well established roles in the development of malignant diseases. Numerous bodies of work have highlighted miRNAs (microRNAs) as critical regulators of tumor pathways and it is clear that the dysregulation of cellular miRNA expression ca...
作者:Florczyk Urszula , Golda Slawomir , Zieba Agata ...
来源:[J].Cancer Letters, 2010, Vol.300 (1), pp.40-7PubMed
摘要:Biliverdin reductase (BVR) converts biliverdin to bilirubin. Additionally, acting as a transcription factor and possessing a capacity of a serine/threonine kinase, it may modulate signaling pathways. In order to gain better understanding of BVR functions, we used genetically...

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