全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Hannah Oh , Sally B. Coburn , Charles E. Matthews ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height,...
作者:Josee-Lyne Ethier , Danielle Desautels , Arnoud Templeton ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:The presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. Here, we quantify the effect of NLR on survival in patients with breast cancer, and examine the effect of clinicopathologic factors on its prognostic ...
作者:Nusayba Bagegni , Shana Thomas , Ning Liu ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated prognostic value in patients with early-stage breast cancer. Because cy...
作者:Lauren E. McCullough , Jia Chen , Yoon Hee Cho ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast cancer-related genes, as well as global methylation, may modify the as...
作者:Jia Yu , Bo Qin , Ann M. Moyer ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting. However, in the setting of operable breast cancer, PDX models both sen...
作者:Edward P. Carter , James A. Gopsill , Jennifer. J. Gomm ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers, researchers now have access to primary patient cells, providing the pe...
作者:Elsa Curtit , Xavier Pivot , Julie Henriques ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk o...
作者:Nguyen M. Nguyen , Fabia de Oliveira Andrade , Lu Jin ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primordial germ cells travel to the genital ridge and st...
作者:Minako Sakurai , Yasuhiro Miki , Kiyoshi Takagi ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma–adipose stromal cell (ASC) interactions have been considered pivotal in supporting tumor growth in breast cancer. In addition, it has been demonstrat...
作者:Meghan Morrison Joly , Michelle M. Williams , Donna J. Hicks ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)Springer
摘要:The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2- amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and resistance to human epidermal growth factor recep...

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