全部文献期刊会议图书|学者科研项目
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作者:Concetta Di Natale , Sara La Manna , Concetta Avitabile ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.96
摘要:Abstract(#br)The investigation of conformational features of regions of amyloidogenic proteins are of great interest to deepen the structural changes and consequent self-aggregation mechanisms at the basis of many neurodegenerative diseases. Here we explore the effect of β-h...
作者:Jie Wang , Qing-Bo Liu , Zi-Lin Hou ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.95
摘要:Abstract(#br)A phytochemical study on the roots of Daphne genkwa yielded seven new guaiane-type sesquiterpenoids ( 1 – 7 ), daphne A-G. Their structures were elucidated through comprehensive spectroscopic analyses. The absolute configurations were determined by comparison be...
作者:Tatyana A. Tikhonova , Irina V. Rassokhina , Eugeny A. Kondrakhin ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.94
摘要:Abstract(#br)Structure–activity relationship studies were conducted in the search for 1,3-thiazole isosteric analogs of imidazopyridine drugs (Zolpidem, Alpidem). Three series of novel γ-aminobutyric acid receptor (GABA A R) ligands belonging to imidazo[2,1- b ]thiazoles, im...
作者:Eman M. Ahmed , Marwa S.A. Hassan , Afaf A. El-Malah ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.95
摘要:Abstract(#br)New pyridazinone and pyridazinthione derivatives were designed, synthesized and identified through performing 1 H NMR, 13 C NMR, IR and MS spectroscopic techniques. All the newly synthesized derivatives were evaluated for cyclooxygenase inhibitory activity and C...
作者:Yang Liu , Mingxue Li , Yujie Zhang ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.96
摘要:Abstract(#br)Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 ( E )-N′-(2,3,...
作者:Nagalakshmamma Vadabingi , Vijaya Kumar Reddy Avula , Grigory V. Zyryanov ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.97
摘要:Abstract(#br)A series of novel α -methyl- l -DOPA urea derivatives viz. , 3-(3,4-dihydroxyphenyl)-2-methyl-2-(3-halo/trifluoromethyl substituted phenyl ureido)propanoic acids ( 6a-e ) have been synthesized from the reaction of α -methyl- l -DOPA (3) with various aryl isocyan...
作者:Yali Sang , Christophe Pannecouque , Erik De Clercq ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.96
摘要:Abstract(#br)Twenty-seven derivatives ( 40 – 66 ) were generated by pharmacophore fusing of sulfonylacetanilide-diarylpyrimidine ( 1 ) with rilpivirine or biphenyl-diarylpyrimidines. They displayed up to single-digit nanomolar activity against wild-type (WT) virus and variou...
作者:Shi Cai , Xiaojun Yang , Pan Chen ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.94
摘要:Abstract(#br)Indoleamine 2,3-dioxygenase 1 (IDO1) plays a vital role in tumor immune escape and has emerged as a promising target for cancer immunotherapy. In this study, a novel series of bicyclic carboxylic acid derivatives were designed, synthesized and evaluated for inhibitor...
作者:Wei-Feng Dai , Yan-Xia Zhu , Fu-Ying Qin ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.97
摘要:Abstract(#br)(±)-Petchilactones A–C ( 1 – 3 ), three pairs of enantiomeric meroterpenoids respectively with a 6/6/5/5 or a 5/5/5/7/6 ring system were isolated from Ganoderma petchii. Their structures including absolute configurations were assigned by using spectroscopic...
作者:Xiaoguang Liu , Xiuxiu Dong , Chuanchuan He ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.96
摘要:Abstract(#br)Iron depletion is an efficient strategy for the development of anticancer agents. In an effort to develop efficient chelators, two new 3-hydroxy-4-pyridinone based polyazamacrocycles 1e and 2e were designed and synthesized. A preliminary study of the ligands was carr...

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