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作者:G. Rex Sumsion , Michael S. Bradshaw , Jeremy T. Beales ...
来源:[J].Biology Direct(IF 2.72), 2020, Vol.15 (1-3), pp.1310-1317
摘要:Abstract(#br)Background(#br)Drug-induced liver injury (DILI) is a serious concern during drug development and the treatment of human disease. The ability to accurately predict DILI risk could yield significant improvements in drug attrition rates during drug development, in ...
作者:Mohamed Omari , Alexander Lange , Julia Plöntzke ...
来源:[J].Biology Direct(IF 2.72), 2020, Vol.15 (8), pp.4022-32
摘要:Abstract(#br)Background(#br)Nutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production after calving. Here, elongated periods of a...
作者:Jay T. Lennon , Kenneth J. Locey
来源:[J].Biology Direct(IF 2.72), 2020, Vol.15 (3), pp.e3000106-5975
摘要:Abstract(#br)Until recently, our planet was thought to be home to ~ 107 species, largely belonging to plants and animals. Despite being the most abundant organisms on Earth, the contribution of microbial life to global biodiversity has been greatly underestimated and, ...
作者:Yuan Jin , Jianglin Zhou , Jing Zhou ...
来源:[J].Biology Direct(IF 2.72), 2020, Vol.15 (4), pp.2046-533
摘要:Abstract(#br)Background(#br)Accurate classification of different Burkholderia cepacia complex (BCC) species is essential for therapy, prognosis assessment and research. The taxonomic status of BCC remains problematic and an improved knowledge about the classification of BCC is in...
作者:Marco Chierici , Margherita Francescatto , Nicole Bussola ...
来源:[J].Biology Direct(IF 2.72), 2020, Vol.15 (1), pp.5-20
摘要:Abstract(#br)Background(#br)Drug-induced liver injury (DILI) is a major concern in drug development, as hepatotoxicity may not be apparent at early stages but can lead to life threatening consequences. The ability to predict DILI from in vitro data would be a crucial advanta...
作者:Marie Gerlitz , Michael Knopp , Nils Kapust ...
来源:[J].Biology Direct(IF 2.72), 2018, Vol.13 (1), pp.1-12
摘要:Abstract Background The origin of eukaryotic cells was an important transition in evolution. The factors underlying the origin and evolutionary success of the eukaryote lineage are still discussed. One camp argues that mitochondria were essential for eukaryote origin because of t...
作者:Alejandro R. Walker , Tyler L. Grimes , Somnath Datta ...
来源:[J].Biology Direct(IF 2.72), 2018, Vol.13 (1), pp.1-16
摘要:Abstract Background Microbial communities can be location specific, and the abundance of species within locations can influence our ability to determine whether a sample belongs to one city or another. As part of the 2017 CAMDA MetaSUB Inter-City Challenge, next generation s...
作者:Irina Sorokina , Arcady Mushegian
来源:[J].Biology Direct(IF 2.72), 2018, Vol.13 (1), pp.1-14
摘要:Abstract A half century of studying protein folding in vitro and modeling it in silico has not provided us with a reliable computational method to predict the native conformations of proteins de novo, let alone identify the intermediates on their folding pathways. In this Op...
作者:Zachary N. Harris , Eliza Dhungel , Matthew Mosior ...
来源:[J].Biology Direct(IF 2.72), 2019, Vol.14 (1), pp.1-13
摘要:Abstract Background Metagenomics is the application of modern genomic techniques to investigate the members of a microbial community directly in their natural environments and is widely used in many studies to survey the communities of microbial organisms that live in diverse eco...
作者:Léon-Charles Tranchevent , Petr V. Nazarov , Tony Kaoma ...
来源:[J].Biology Direct(IF 2.72), 2018, Vol.13 (1), pp.1-13
摘要:Abstract Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being produced. For instance, large cohorts of patients are often screened using different high-throughput technolog...

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