全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Brian K. Chu , Margaret J. Tse , Royce R. Sato ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Gene regulatory networks with dynamics characterized by multiple stable states underlie cell fate-decisions. Quantitative models that can link molecular-level knowledge of gene regulation to a global understanding of network dynamics have the potential to guide cell-reprogramming...
作者:Niek Welkenhuysen , Johannes Borgqvist , Mattias Backman ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:The yeast AMPK/SNF1 pathway is best known for its role in glucose de/repression. When glucose becomes limited, the Snf1 kinase is activated and phosphorylates the transcriptional repressor Mig1, which is then exported from the nucleus. The exact mechanism how the Snf1-Mig1 pathwa...
作者:Cong-Doan Truong , Yung-Keun Kwon
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (7)Springer
摘要:Biological networks consisting of molecular components and interactions are represented by a graph model. There have been some studies based on that model to analyze a relationship between structural characteristics and dynamical behaviors in signaling network. However, little at...
作者:Jian Yang , Tinghong Yang , Duzhi Wu ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Physical and functional interplays between genes or proteins have important biological meaning for cellular functions. Some efforts have been made to construct weighted gene association meta-networks by integrating multiple biological resources, where the weight indicates the con...
作者:Abraham A. Labena , Yuan-Nong Ye , Chuan Dong ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Essential reactions are vital components of cellular networks. They are the foundations of synthetic biology and are potential candidate targets for antimetabolic drug design. Especially if a single reaction is catalyzed by multiple enzymes, then inhibiting the reaction would be ...
作者:Richard Ballweg , Frederick Schozer , Kelsey Elliott ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Helicobacter Pylori (HP) is the most common risk factor for gastric cancer. Nearly half the world’s population is infected with HP, but only a small percentage of those develop significant pathology. The bacteria itself does not directly cause cancer; rather it promotes an e...
作者:Rakesh Pandey , Judith P. Armitage , George H. Wadhams
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Photosynthetic (PS) gene expression in Rhodobacter sphaeroides is regulated in response to changes in light and redox conditions mainly by PrrB/A, FnrL and AppA/PpsR systems. The PrrB/A and FnrL systems activate the expression of them under anaerobic conditions while the AppA/Pps...
作者:Juan A. Botía , Jana Vandrovcova , Paola Forabosco ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used R software package for the generation of gene co-expression networks (GCN). WGCNA generates both a GCN and a derived partitioning of clusters of genes (modules). We propose k-means clustering as an additional p...
作者:Ben-gong Zhang , Weibo Li , Yazhou Shi ...
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (7)Springer
摘要:Detecting causality for short time-series data such as gene regulation data is quite important but it is usually very difficult. This can be used in many fields especially in biological systems. Recently, several powerful methods have been set up to solve this problem. However, i...
作者:Joanna H. Sier , Alfred E. Thumser , Nick J. Plant
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)Springer
摘要:Estrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both sexes, plus uterine angiogenesis and proliferation during the menstrual cycle and pregnancy in women. The varie...

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