全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Wei-Lin Hu , Xiong-Hui Zhou
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (4)Springer
摘要:The identification of prognostic biomarkers for cancer patients is essential for cancer research. These days, DNA methylation has been proved to be associated with cancer prognosis. However, there are few methods which identify the prognostic markers based on DNA methylation data...
作者:Donavan T. Cheng , Meera Prasad , Yvonne Chekaluk ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:The growing number of Next Generation Sequencing (NGS) tests is transforming the routine clinical diagnosis of hereditary cancers. Identifying whether a cancer is the result of an underlying disease-causing mutation in a cancer predisposition gene is not only diagnostic for a can...
作者:Jian-Yu Shi , Hua Huang , Yan-Ning Zhang ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (4)Springer
摘要:In human genomes, long non-coding RNAs (lncRNAs) have attracted more and more attention because their dysfunctions are involved in many diseases. However, the associations between lncRNAs and diseases (LDA) still remain unknown in most cases. While identifying disease-related lnc...
作者:Jack Humphrey , Warren Emmett , Pietro Fratta ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion cause...
作者:Guo Cheng , Patrick Ho-Yu Chung , Edwin Kin-Wai Chan ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:Biliary Atresia (BA) is rare and genetically complex, and the pathogenesis is elusive. The disease course is variable and can represent heterogeneity, which hinders effective disease management. Deciphering the BA phenotypic variance is a priority in clinics and can be achieved b...
作者:Zhan Zhou , Shanshan Wu , Jun Lai ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:Intratumor heterogeneity (ITH) poses an urgent challenge for cancer precision medicine because it can cause drug resistance against cancer target therapy and immunotherapy. The search for trunk mutations that are present in all cancer cells is therefore critical for each patient.
作者:Jonathan B. Dayton , Stephen R. Piccolo
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (4)Springer
摘要:Malignant tumors are typically caused by a conglomeration of genomic aberrations—including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug treatments are effective against tumors t...
作者:João Sá Sousa , Cédric Lefebvre , Zhicong Huang ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (2)Springer
摘要:Cloud computing is becoming the preferred solution for efficiently dealing with the increasing amount of genomic data. Yet, outsourcing storage and processing sensitive information, such as genomic data, comes with important concerns related to privacy and security. This calls fo...
作者:Yang Hu , Meng Zhou , Hongbo Shi ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (5)Springer
摘要:Similar diseases are always caused by similar molecular origins, such as diasease-related protein-coding genes (PCGs). And the molecular associations reflect their similarity. Therefore, current methods for calculating disease similarity often utilized functional interactions of ...

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