全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Enfeng Qi , Dongyu Wang , Bo Gao ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:The mechanism of action of proteases has been widely studied based on substrate specificity. Prior research has been focused on the amino acids at a single amino acid site, but rarely on combinations of amino acids around the cleavage bond.
作者:Mohsen Sharifi , Dan Buzatu , Stephen Harris ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (14)Springer
摘要:Blockage of some ion channels and in particular, the hERG (human Ether-a’-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrhythmia known as Torsade de Pointes (T...
作者:Georgios A. Dalkas , Marianne Rooman
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:The identification of immunogenic regions on the surface of antigens, which are able to be recognized by antibodies and to trigger an immune response, is a major challenge for the design of new and effective vaccines. The prediction of such regions through computational immunolog...
作者:Sérgio E. D. Dias , Ana Mafalda Martins , Quoc T. Nguyen ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Protein cavities play a key role in biomolecular recognition and function, particularly in protein-ligand interactions, as usual in drug discovery and design. Grid-based cavity detection methods aim at finding cavities as aggregates of grid nodes outside the molecule, under the c...
作者:Vassily Lyubetsky , Roman Gershgorin , Konstantin Gorbunov
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Chromosome structure is a very limited model of the genome including the information about its chromosomes such as their linear or circular organization, the order of genes on them, and the DNA strand encoding a gene. Gene lengths, nucleotide composition, and intergenic regions a...
作者:Meiling Liu , Sanghoon Moon , Longfei Wang ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Copy number variation (CNV) is known to play an important role in the genetics of complex diseases and several methods have been proposed to detect association of CNV with phenotypes of interest. Statistical methods for CNV association analysis can be categorized into two differe...
作者:Jennifer A. Tom , Jens Reeder , William F. Forrest ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Large sample sets of whole genome sequencing with deep coverage are being generated, however assembling datasets from different sources inevitably introduces batch effects. These batch effects are not well understood and can be due to changes in the sequencing protocol or bioinfo...
作者:Sharma V. Thankachan , Sriram P. Chockalingam , Yongchao Liu ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (8)Springer
摘要:Alignment-free sequence comparison approaches have been garnering increasing interest in various data- and compute-intensive applications such as phylogenetic inference for large-scale sequences. While k -mer based methods are predominantly used in real applications, the average ...

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