全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Robert D. Bongard , Michael Lepley , Khushabu Thakur ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficul...
作者:Edna Blotnick , Asaf Sol , Gilad Bachrach ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Histatins are histidine rich polypeptides produced in the parotid and submandibular gland and secreted into the saliva. Histatin-3 and −5 are the most important polycationic histatins. They possess antimicrobial activity against fungi such as Candida albicans. Histatin-5 has...
作者:Gopinath Muruganandam , Arne Raasakka , Matti Myllykoski ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5′-phosphate ligation involves two steps: a healing reaction catalyzed by polynucleotide kinase (PNK) in association with cyclic phosph...
作者:Bin Zhou , Gang Liu , Qiyi He ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Mice were bitten by five-pace vipers ( Deinagkistrodon acutus ), and then envenomed. It was well-known that the snake venom mainly disturbed the blood homeostasis of the envenomed victims. Ocassionally, we found that the venom of D. acutus could inhibit the contraction tension of...
作者:Mario A. Bianchet , Ying H. Pan , Leighanne A. Brammer Basta ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical transpeptidases (L,D-transpeptidases) that generate 3 → 3 linkages in ...
作者:Arina Marina Perez , Bruno Aquino , Vadim Viviani ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Luciferases, enzymes that catalyze bioluminescent reactions in different organisms, have been extensively used for bioanalytical purposes. The most well studied bioluminescent system is that of firefly and other beetles, which depends on a luciferase, a benzothiazolic luciferin a...
作者:Burzin Chavda , Jun Ling , Thomas Majernick ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis—a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelial cells and cancer cells in vitro, presumably by binding to its ce...
作者:Annegret Ulke-Lemée , David Hao Sun , Hiroaki Ishida ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process. SMTNL1 is phosphorylated at Ser301 by protein kinase A during calcium desensitization in smooth muscle, yet the effec...
作者:Hideki Shimura , Ryota Tanaka , Yoshiaki Shimada ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Peptides with cytoprotective functions, including antioxidants and anti-infectives, could be useful therapeutics. Carnosine, β-alanine-histidine, is a dipeptide with anti-oxidant properties. Tripeptides of Ala-His-Lys, Pro-His-His, or Tyr-His-Tyr are also of interest in this...
作者:Xiaowen Fei , Junmei Yu , Yajun Li ...
来源:[J].BMC Biochemistry(IF 1.776), 2017, Vol.18 (1)Springer
摘要:Under iron-deficient conditions, Chlamydomonas exhibits high affinity for iron absorption. Nevertheless, the response, transmission, and regulation of downstream gene expression in algae cells have not to be investigated. Considering that the MAPK pathway is essential for abiotic...

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