全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Martin R. Schmuck , Thomas Temme , Katharina Dach ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (4), pp.2017-2028Springer
摘要:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-c...
作者:Barbara Witt , Sören Meyer , Franziska Ebert ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (9), pp.3121-3134Springer
摘要:Arsenolipids are lipid-soluble organoarsenic compounds, mainly occurring in marine organisms, with arsenic-containing hydrocarbons (AsHCs) and arsenic-containing fatty acids (AsFAs) representing two major subgroups. Recently, toxicity studies of several arsenolipids showed a...
作者:Sebastian T. Soukup , Dennis R. Müller , Anne Kurrat ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (4), pp.1649-1661Springer
摘要:Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption ...
作者:Katharina Jarolim , Giorgia Del Favero , Doris Ellmer ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (4), pp.2007-2016Springer
摘要:Type II DNA-topoisomerases (topo II) play a crucial role in the maintenance of DNA topology. Previously, fungi of the Alternaria genus were found to produce mycotoxins that target human topo II. These results implied the question why a fungus should produce secondary metabol...
作者:Sivakumar Murugadoss , Dominique Lison , Lode Godderis ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (9), pp.2967-3010Springer
摘要:Large-scale production and use of amorphous silica nanoparticles (SiNPs) have increased the risk of human exposure to SiNPs, while their health effects remain unclear. In this review, scientific papers from 2010 to 2016 were systematically selected and sorted based on in vit...
作者:Antonio F. Hernández , Fernando Gil , Marina Lacasaña
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (10), pp.3211-3223Springer
摘要:Pesticides can interact with each other in various ways according to the compound itself and its chemical family, the dose and the targeted organs, leading to various effects. The term interaction means situations where some or all individual components of a mixture influenc...
作者:Hoa Thanh Nguyen , Maria Claret Lauan Tsuchiya , Jean Yoo ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (4), pp.1763-1782Springer
摘要:Dioxins cause various toxic effects through the aryl hydrocarbon receptor (AHR) in vertebrates, with dramatic species and strain differences in susceptibility. Although inbred mouse strains C3H/HeJ- lpr/lpr (C3H/ lpr ) and MRL/MpJ- lpr/lpr (MRL/ lpr ) are known as dioxin-sen...
作者:Hye Young Kim , Woo Young Kwon , Yeon A. Kim ...
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (6), pp.2353-2363Springer
摘要:Although epidemiological and experimental studies demonstrated that polychlorinated biphenyls (PCBs) lead to insulin resistance, the mechanism underlying PCBs-induced insulin resistance has remained unsolved. In this study, we examined in vitro and in vivo effects of PCB-118 (dio...

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