全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Venkata Ramana Naidu , Rucha S. Deshpande , Moinuddin R. Syed ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (6), pp.2045-2054Springer
摘要:Current endeavor was aimed towards monitoring percent weight build-up during functional coating process on drug-layered pellets. Near-infrared (NIR) spectroscopy is an emerging process analytical technology (PAT) tool which was employed here within quality by design (QbD) fr...
作者:A. Patil , S. Singh , C. Opere ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (6), pp.2291-2302Springer
摘要:Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S coul...
作者:Yongquan Li , Yu Xiao , Zongning Yin
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (3), pp.729-737Springer
摘要:As an effective COX-2 inhibitor, celecoxib is widely used in anti-inflammation therapy. However, it may cause cardiovascular risks and renal adverse effects. In the present study, we aimed to construct a celecoxib prodrug with enhanced anti-inflammatory efficacy and reduced adver...
作者:Aoke Wang , Aftab Ahmad , Sadeeq Ullah ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (8), pp.3227-3235Springer
摘要:Liposomes, the biocompatible lipid bilayer vesicles, have attracted immense attention due to their distinctive features such as efficient vehicle for the delivery of a wide range of therapeutic agents, adjustable formulation properties, and high drug entrapment efficiency. I...
作者:Yuki Takechi-Haraya , Kumiko Sakai-Kato , Yukihiro Goda
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (5), pp.1887-1893Springer
摘要:We determined the permeability coefficient of a model hydrophilic drug, calcein, encapsulated within saturated lipid-based nano-sized liposomes of various lipid profiles. We demonstrated that the addition of cholesterol to liposomes containing saturated lipids increased the perme...
作者:Riddhish Patadia , Chintan Vora , Karan Mittal ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (4), pp.1213-1227Springer
摘要:The research was envisaged for development of time-controlled pulsatile release (PR) platform formulation to facilitate management of early morning chronological attacks. The development was started using prednisone as a model drug wherein core tablets were prepared using di...
作者:Hongmei Xia , Yinxiang Xu , Zhiqing Cheng ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (5), pp.1720-1727Springer
摘要:Tetramethylpyrazine (TMP) was extracted from Ligusticum chuanxiong hort . The compound is known to have a variety of medicinal functions; in particular, it is used for the treatment of cerebral ischemic diseases. TMP-loaded hydrogels offer an excellent preparation with the capaci...
作者:M. Sacchetti , R. Teerakapibal , K. Kim ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (6), pp.2214-2226Springer
摘要:Drugs formulated as tablets are subjected to accelerated stability conditions with the goal of identifying a stable formulation that will exhibit a sufficiently long shelf life. Water sorption at a condition such as 40°C/75% RH can result in significant changes in tablet pro...
作者:Jung-Myung Ha , Jeong-Woong Seo , Su-Hyeon Kim ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (8), pp.3129-3139Springer
摘要:The purpose of the present study was to develop a rebamipide (RBM) gastro-retentive (GR) tablet by implementing quality by design (QbD). RBM GR tablets were prepared using a sublimation method. Quality target product profile (QTPP) and critical quality attributes (CQAs) of the RB...

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