全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Zhang Guisen , Huang Zhuo
来源:[J].Molecules (Basel, Switzerland)(IF 2.428), 2018, Vol.23 (5)PubMed
摘要:GLYX-13, a NMDAR glycine-site partial agonist, was discovered as a promising antidepressant with rapidly acting effects but no ketamine-like side effects. However, the reported synthetic process route had deficiencies of low yield and the use of unfriendly reagents. Here, we repo...
作者:Zhang Guisen , Song Xueqin ...
来源:[J].Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Vol.46 (6), pp.2358-2372PubMed
摘要:Myelination, degeneration and regeneration are implicated in crucial responses to injury in the peripheral nervous system. Considering the progression of amyotrophic lateral sclerosis (ALS), we used the superoxide dismutase 1 (SOD1)-G93A transgenic mouse model of ALS to investiga...
作者:... Wang Tao , Zhang Guisen , Li Qingeng
来源:[J].Chemical biology & drug design, 2016, Vol.88 (1), pp.38-42PubMed
摘要:A new water-soluble benzodiazepine derivative, CNS 7056 (named as remimazolam), has been undergoing many reactions in recent years to provide an intravenous agent with a predictable fast-onset, short duration of action, and rapid recovery profile. Based on the structure of C...
作者:Zhang Guisen , Li Yan ...
来源:[J].Medicine, 2016, Vol.95 (37), pp.e4905PubMed
摘要:The aim of this study was to investigate the prevalence and causes of low vision and blindness in Baotou, Inner Mongolia.A cross-sectional study was carried out. Multistage sampling was used to select samples. The visual acuity was estimated using LogMAR and corrected by pinhole ...
作者:Zhang Guisen , Tham Yih-Chung ...
来源:[J].The British journal of ophthalmology, 2018PubMed
摘要:To determine the prevalence and causes of visual impairment (VI), and to describe the characteristics of cataract surgery coverage and related barriers among adults aged ≥50 years residing in Hohhot, Inner Mongolia.;;A population-based cross-sectional study was performed. Pr...
作者:... Hou Yuanyuan , Zhang Guisen , Wang Kewei
来源:[J].The Journal of pharmacology and experimental therapeutics, 2018PubMed
摘要:Multi-target antidepressants selectively inhibiting monoaminergic transporters and 5-HT2A receptors have demonstrated higher efficacy and fewer side effects than selective serotonin reuptake inhibitors (SSRIs). In the present study, we synthesized a series of novel 3-(benzo[d] [1...
作者:Zhang Yifang , Lan Yu ...
来源:[J].Journal of medicinal chemistry, 2016, Vol.59 (7), pp.2942-61PubMed
摘要:By use of the 6-hydroxypyridazinone framework, a new series of potent σ1 receptor ligands associated with pharmacological antineuropathic pain activity was synthesized and is described in this article. In vitro receptor binding studies revealed high σ1 receptor affinity (Ki ...
作者:Zhang Guisen , Zhang Liangren
来源:[J].European journal of medicinal chemistry, 2016, Vol.115, pp.94-108PubMed
摘要:Human α7 nicotinic acetylcholine receptor (nAChR) is a promising therapeutic target for the treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the synthesis and agonistic activities of a series of indolizine derivatives targeting to α7 nAChR....
作者:Zhang Wen , Cao Longji ...
来源:[J].Journal of pharmaceutical and biomedical analysis, 2018, Vol.152, pp.188-196PubMed
摘要:Olanzapine is a marketed antipsychotic agent for treatment of both positive and negative symptoms of schizophrenia. The chemical synthesis of olanzapine drug substance involved the reaction of thienobenzodiazepine hydrochloride with N-methylpiperazine. During the manufacture of o...
作者:马彦琴 , 赵世魁 , 张桂森 ...
来源:[J].中国医药工业杂志, 2013, (06), pp.554-556CNKI
摘要:1-(3-甲氧基苯基)-1-丙酮与N,N-二甲基氯甲胺经烃化及手性拆分得到(S)-3-(二甲胺基)-1-(3-甲氧基苯基)-2-甲基丙酮,与乙基膦酸二乙酯经Horner-Emmons-Wittig反应及催化氢化制得(2R,3R)-3-(3-甲氧基苯基)-N,N,2-三甲基戊胺,最...
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