全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Zhang Guisen , Huang Zhuo
来源:[J].Molecules (Basel, Switzerland)(IF 2.428), 2018, Vol.23 (5)PubMed
摘要:GLYX-13, a NMDAR glycine-site partial agonist, was discovered as a promising antidepressant with rapidly acting effects but no ketamine-like side effects. However, the reported synthetic process route had deficiencies of low yield and the use of unfriendly reagents. Here, we repo...
作者:Zhang Guisen , Liu Lei
来源:[J].Diabetes therapy : research, treatment and education of diabetes and related disorders, 2019PubMed
摘要:INTRODUCTION(#br)The relationship of total cholesterol (TC) or triglyceride (TG) to diabetic retinopathy (DR) has proven difficult to determine. In addition, there is no report of any study of the correlation between the TC/TG ratio and DR. This study was therefore undertaken to ...
作者:Zhang Jie , Bi Yue ...
来源:[J].Aging(IF 4.696), 2019PubMed
摘要:Haploinsufficiency of the protein kinase Tbk1 has shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the pathogenic mechanisms are unclear. Here we show that conditional neuronal deletion of Tbk1 in leads to cognitive and locomotor...
作者:Zhang Guisen , Liu Lei
来源:[J].Diabetes, metabolic syndrome and obesity : targets and therapy, 2019, Vol.12, pp.513-518PubMed
摘要:Purpose: Abnormal levels of lipid accumulation product (LAP) have been associated with risk of cardiovascular disease and diabetes. However, it is not clear whether LAP index is associated with diabetic retinopathy (DR). We investigated the association between LAP index and ...
作者:Zhang Guisen , Song Xueqin ...
来源:[J].Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Vol.46 (6), pp.2358-2372PubMed
摘要:Myelination, degeneration and regeneration are implicated in crucial responses to injury in the peripheral nervous system. Considering the progression of amyotrophic lateral sclerosis (ALS), we used the superoxide dismutase 1 (SOD1)-G93A transgenic mouse model of ALS to investiga...
作者:... Wang Tao , Zhang Guisen , Li Qingeng
来源:[J].Chemical biology & drug design, 2016, Vol.88 (1), pp.38-42PubMed
摘要:A new water-soluble benzodiazepine derivative, CNS 7056 (named as remimazolam), has been undergoing many reactions in recent years to provide an intravenous agent with a predictable fast-onset, short duration of action, and rapid recovery profile. Based on the structure of C...
作者:Zhang Guisen , Li Yan ...
来源:[J].Medicine, 2016, Vol.95 (37), pp.e4905PubMed
摘要:The aim of this study was to investigate the prevalence and causes of low vision and blindness in Baotou, Inner Mongolia.A cross-sectional study was carried out. Multistage sampling was used to select samples. The visual acuity was estimated using LogMAR and corrected by pinhole ...
作者:Zhang Guisen , Tham Yih-Chung ...
来源:[J].The British journal of ophthalmology, 2018PubMed
摘要:To determine the prevalence and causes of visual impairment (VI), and to describe the characteristics of cataract surgery coverage and related barriers among adults aged ≥50 years residing in Hohhot, Inner Mongolia.;;A population-based cross-sectional study was performed. Pr...
作者:... Hou Yuanyuan , Zhang Guisen , Wang Kewei
来源:[J].The Journal of pharmacology and experimental therapeutics, 2018PubMed
摘要:Multi-target antidepressants selectively inhibiting monoaminergic transporters and 5-HT2A receptors have demonstrated higher efficacy and fewer side effects than selective serotonin reuptake inhibitors (SSRIs). In the present study, we synthesized a series of novel 3-(benzo[d] [1...
作者:Zhang Yuxin , Chen Yin
来源:[J].Bioorganic & medicinal chemistry letters, 2019PubMed
摘要:The synthesis and H3 receptor ligand of a new series of lactam derivatives are reported. The new compounds were evaluated in vitro in H3 and H1 receptor-binding assays. The structure-activity relationship led us to the promising derivative 2-methy...

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