全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Guo Bingyu , Hui Qiang ...
来源:[J].Aging(IF 4.696), 2019, Vol.11 (9), pp.2898-2910PubMed
摘要:Noncoding RNAs are known to be importantly involved in a variety physiological and pathophysiolgical processes. Their role in the pathogenesis of hypertrophic scars remains unclear, however. After preliminary screening of the microRNA (miRNA) gene expression profiles, we explored...
作者:Guo Bingyu , Lin Shixiu ...
来源:[J].Aging(IF 4.696), 2019PubMed
摘要:The naturally occurring compound apigenin has many biological effects, including anti-inflammatory, antioxidative and anticancer effects. Although hypertrophic scar formation is a common surgical complication, there is still no good treatment for it. In the present study, we exam...
作者:Guo Bingyu , Zhang Qian ...
来源:[J].Aging(IF 4.696), 2018, Vol.10 (4), pp.632-644PubMed
摘要:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma....
作者:Guo Bingyu , Hui Qiang ...
来源:[J].Oncotarget(IF 6.636), 2017, Vol.8 (15), pp.25226-25241PubMed
摘要:A novel bioartificial dermal regeneration template has been developed using platelet-rich plasma and acellular animal skin collagen sponge for the treatment of larger area and full thickness skin wounds. This platelet-rich plasma-collagen sponge keeps native skin structure and co...
作者:Guo Bingyu , Chang Peng ...
来源:[J].BioMed research international, 2019, Vol.2019, pp.8214923PubMed
摘要:The aim of this study was to detect abnormally expressed microRNA (miRNA) in keloids and to study their functions. The differential expression of miRNAs in keloids and normal tissue was detected by gene microarray. MiRNA expression was verified by real-time PCR. A luciferase repo...
作者:Guo Bingyu , Hui Qiang ...
来源:[J].Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Vol.49 (3), pp.IPubMed
摘要:BACKGROUND/AIMS(#br)There are few effective treatment options for hypertrophic scars. MircoRNAs are a class of small, noncoding RNAs involved in multiple biological functions.(#br)METHODS(#br)Gene chip screening was used to screen out the differential expression of miRNAs in...
作者:Guo Bingyu , Li Xiaodong ...
来源:[J].Oncology reports, 2016, Vol.35 (4), pp.2246-56PubMed
摘要:(-)-β-hydrastine is one of the main active components of the medicinal plant, Hydrastis canadensis, which is used in many dietary supplements intended to enhance the immune system. However, whether (-)-β-hydrastine affects the tumor signaling pathway remains unexplored. In t...
作者:Guo Bingyu , Xie Peng ...
来源:[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Vol.37 (2), pp.2709-19PubMed
摘要:Glioblastoma multiforme (GBM) is one of the most palindromic and malignant central nervous system neoplasms, and the current treatment is not effectual for GBM. Research of specific medicine for GBM is significant. Fangchinoline possesses a wide range of pharmacological activitie...
作者:Guo Bingyu , Hui Qiang ...
来源:[J].Oncology reports, 2016, Vol.36 (4), pp.2412-20PubMed
摘要:The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provi...
作者:Guo Bingyu , Guo Jing ...
来源:[J].Organic & biomolecular chemistry, 2016, Vol.14 (32), pp.7676-90PubMed
摘要:A new series of novel 1-phenanthryl-tetrahydroisoquinoline derivatives were designed, synthesized and biologically evaluated for their PAK4 inhibitory activities and anti-proliferative effects against three cancer cell lines A549, MCF-7 and HT-1080. Among them, compound 12a ...

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