全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Guo Bingyu , Zhang Qian ...
来源:[J].Aging(IF 4.696), 2018PubMed
摘要:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma....
作者:Guo Bingyu , Hui Qiang ...
来源:[J].Oncotarget(IF 6.636), 2017, Vol.8 (15), pp.25226-25241PubMed
摘要:A novel bioartificial dermal regeneration template has been developed using platelet-rich plasma and acellular animal skin collagen sponge for the treatment of larger area and full thickness skin wounds. This platelet-rich plasma-collagen sponge keeps native skin structure and co...
作者:Guo Bingyu , Li Xiaodong ...
来源:[J].Oncology reports, 2016, Vol.35 (4), pp.2246-56PubMed
摘要:(-)-β-hydrastine is one of the main active components of the medicinal plant, Hydrastis canadensis, which is used in many dietary supplements intended to enhance the immune system. However, whether (-)-β-hydrastine affects the tumor signaling pathway remains unexplored. In t...
作者:Guo Bingyu , Xie Peng ...
来源:[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Vol.37 (2), pp.2709-19PubMed
摘要:Glioblastoma multiforme (GBM) is one of the most palindromic and malignant central nervous system neoplasms, and the current treatment is not effectual for GBM. Research of specific medicine for GBM is significant. Fangchinoline possesses a wide range of pharmacological activitie...
作者:Guo Bingyu , Hui Qiang ...
来源:[J].Oncology reports, 2016, Vol.36 (4), pp.2412-20PubMed
摘要:The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provi...
作者:Guo Bingyu , Guo Jing ...
来源:[J].Organic & biomolecular chemistry, 2016, Vol.14 (32), pp.7676-90PubMed
摘要:A new series of novel 1-phenanthryl-tetrahydroisoquinoline derivatives were designed, synthesized and biologically evaluated for their PAK4 inhibitory activities and anti-proliferative effects against three cancer cell lines A549, MCF-7 and HT-1080. Among them, compound 12a ...
作者:Guo Bingyu , Su Jingyuan ...
来源:[J].Journal of drug targeting, 2015, Vol.23 (3), pp.266-74PubMed
摘要:Fangchinoline as a novel anti-tumor agent has been paid attention in several types of cancers cells except lung cancer. Here we have investigated the effect of fangchinoline on A549 cells and its underlying mechanism.;;The purpose of this work was to study the effect of fang...
作者:Guo Bingyu , Ma Shudan ...
来源:[J].Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Vol.105, pp.1291-1298PubMed
摘要:Hypertrophy is a very common pathologic phenomenon of scar hyperplasia after human skin injury and wound healing. In this article, we first proved that naringin could inhibit the proliferation of fibroblasts by MTT experiments. Flow cytometry indicated that naringin could block t...
作者:Guo Bingyu , Hui Qiang ...
来源:[J].Oncology reports, 2017, Vol.38 (1), pp.63-70PubMed
摘要:Melanoma is a malignant tumor with high degree of malignancy, metastasis and high mortality. The etiology of melanoma has not been fully elucidated, and there is no effective drug for the complete treatment of melanoma. In recent years, many traditional Chinese herbal medici...
作者:Guo Jing , Hao Chenzhou ...
来源:[J].Organic & biomolecular chemistry, 2015, Vol.13 (12), pp.3803-18PubMed
摘要:Functional versatility and elevated expression in cancers have promoted p21-activated kinase 4 (PAK4) as one of the first-in-class anti-cancer drug targets. In this study, a series of novel 1-phenanthryl-tetrahydroisoquinoline analogues have been designed and synthesized as a nov...

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