全部文献期刊会议图书|学者科研项目
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作者:Zhidong Ling , Evert J. Kroon
来源:[J].Stem Cell Reports, 2018, Vol.10 (3), pp.739-750
摘要:Summary(#br)Human stem cells represent a potential source for implants that replace the depleted functional beta cell mass (FBM) in diabetes patients. Human embryonic stem cell-derived pancreatic endoderm (hES-PE) can generate implants with glucose-responsive beta cells capa...
作者:Zhidong Ling , Peter In 't Veld
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (8)
摘要:BACKGROUND: Pancreatic-tail duct ligation (PDL) in adult rodents has been reported to induce beta cell generation and increase beta cell mass but increases in beta cell number have not been demonstrated. This study examines whether PDL increases beta cell number and whether ...
作者:Zhidong Ling , Evert J. Kroon
来源:[J].Stem Cell Reports, 2018, Vol.10 (3), pp.739-750
摘要:Summary: Human stem cells represent a potential source for implants that replace the depleted functional beta cell mass (FBM) in diabetes patients. Human embryonic stem cell-derived pancreatic endoderm (hES-PE) can generate implants with glucose-responsive beta cells capable...
作者:Zhidong Ling , Pieter Gillard ...
来源:[J].Cell Transplantation(IF 4.422), 2017, Vol.26
摘要:Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate immune markers in periphe...
作者:Zhidong Ling , Daniel Pipeleers ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (5)
摘要:AIMS/HYPOTHESIS: Duct cells isolated from adult human pancreas can be reprogrammed to express islet beta cell genes by adenoviral transduction of the developmental transcription factor neurogenin3 (Ngn3). In this study we aimed to fully characterize the extent of this reprogrammi...
作者:Zhidong Ling , Christiaan Van Schravendijk ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.5 (12)
摘要:BACKGROUND AND METHODOLOGY: Pancreatic beta cells show intercellular differences in their metabolic glucose sensitivity and associated activation of insulin production. To identify protein markers for these variations in functional glucose sensitivity, rat beta cell subpopulation...
作者:Zhidong Ling , Harry Heimberg ...
来源:[J].Cell Transplantation(IF 4.422), 2015, Vol.24
摘要:The presence of pancreatic duct cells in clinical islet grafts may affect long-term metabolic success. Human pancreatic duct cells express factors that may exert both protective and damaging effects on islet cells in the graft. Here we studied the potential of commonly used ...
作者:Zhidong Ling , Danny Pipeleers ...
来源:[J].Cell(IF 31.957), 2007, Vol.132 (2), pp.197-207
摘要:Summary(#br)Novel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell stem/progenitor cells. However, whether or not adult β cell progenitors exist is one of the most controversial issues in today's diabetes research. Guided by the expression...
作者:Zhidong Ling , Frans K. Gorus ...
来源:[J].Journal of Immunological Methods(IF 2.225), 2007, Vol.319 (1), pp.133-143
摘要:Abstract(#br)The 65 kDa isoform of human glutamate decarboxylase (GAD65) is a major autoantigen in type 1 diabetes (T1D). In the present study, we have developed a sensitive sandwich time-resolved fluorescence immunoassay (TRFIA) for the quantification of GAD65 in cell extracts, ...
作者:Zhidong Ling , Daniël Pipeleers
来源:[J].Life Sciences(IF 2.555), 2005, Vol.77 (11), pp.1273-1282
摘要:Abstract(#br)The adipocyte-derived hormone adiponectin was recently shown to stimulate glucose-utilization and to increase fatty acid oxidation in liver and muscle. The effects were ascribed to adiponectin-receptor mediated activation of the key metabolic regulator AMP-activ...

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