全部文献期刊会议图书|学者科研项目
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作者:Ugo Bastolla , Yves Dehouck , Julian Echave
来源:[J].Current Opinion in Structural Biology(IF 8.738), 2017, Vol.42, pp.59-66
摘要:The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformation...
作者:... Jaroslav Albert , Yves Dehouck , Alexandre Haye
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (12)
摘要:Available DNA microarray time series that record gene expression along the developmental stages of multicellular eukaryotes, or in unicellular organisms subject to external perturbations such as stress and diauxie, are analyzed. By pairwise comparison of the gene expression profi...
作者:... Malik Dhanani , Yves Dehouck , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (3)
摘要:The ability to rationally modify targeted physical and biological features of a protein of interest holds promise in numerous academic and industrial applications and paves the way towards de novo protein design. In particular, bioprocesses that utilize the remarkable proper...
作者:Yves Dehouck , Christophe Biot ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2003, Vol.330 (5), pp.1215-1225
摘要:Abstract(#br)Three-dimensional domain swapping occurs when two or more identical proteins exchange identical parts of their structure to generate an oligomeric unit. It affects proteins with diverse sequences and structures, and is expected to play important roles in evoluti...
作者:Yves Dehouck , Dimitri Gilis , Marianne Rooman
来源:[J].Biophysical Journal(IF 3.668), 2004, Vol.87 (1), pp.171-181
摘要:Abstract(#br)Knowledge-based potentials are widely used in simulations of protein folding, structure prediction, and protein design. Their advantages include limited computational requirements and the ability to deal with low-resolution protein models compatible with long-sc...
作者:Yves Dehouck , Mariano Casu ...
来源:[J].Journal of Magnetic Resonance(IF 2.3), 2001, Vol.150 (2), pp.167-174
摘要:Abstract(#br)The interaction of xenon with different proteins in aqueous solution is investigated by 129 Xe NMR spectroscopy. Chemical shifts are measured in horse metmyoglobin, hen egg white lysozyme, and horse cytochrome c solutions as a function of xenon concentration. In...
作者:Giulia Gonnelli , Marianne Rooman , Yves Dehouck
来源:[J].Journal of Biotechnology(IF 3.183), 2012, Vol.161 (3), pp.287-293
摘要:Abstract(#br)The ability to rapidly and accurately predict the effects of mutations on the physicochemical properties of proteins holds tremendous importance in the rational design of modified proteins for various types of industrial, environmental or pharmaceutical applications,...
作者:Benjamin Folch , Yves Dehouck , Marianne Rooman
来源:[J].Biophysical Journal(IF 3.668), 2009, Vol.98 (4), pp.667-677
摘要:Abstract(#br)The goal of controlling protein thermostability is tackled here through establishing, by in silico analyses, the relative weight of residue-residue interactions in proteins as a function of temperature. We have designed for that purpose a (melting-) temperature-...
作者:Yves Dehouck , Lisa D. Cabrita ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2003, Vol.325 (3), pp.581-589
摘要:Abstract(#br)α 1 -Antitrypsin, a protein belonging to the serine protease inhibitor (serpin) superfamily, is characterized by the ability to undergo dramatic conformational changes leading to inactive polymers. Serpin polymerization, which causes a range of diseases such as ...
作者:Yves Dehouck , Jean Marc Kwasigroch ...
来源:[J].BMC Bioinformatics(IF 3.024), 2011, Vol.12 (1)
摘要:Abstract(#br) Background(#br)The rational design of modified proteins with controlled stability is of extreme importance in a whole range of applications, notably in the biotechnological and environmental areas, where proteins are used for their catalytic or other functional acti...

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