全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yuna Blum , Silva Kasela ...
来源:[J].Genome Biology, 2017, Vol.18 (1)Springer
摘要:The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish men from the Metabolic Syndrome In Men (METSIM) study.
作者:Yuna Blum , Guillaume Le Mignon ...
来源:[J].BMC Genomics(IF 4.397), 2011, Vol.12 (1)Springer
摘要:Abstract(#br) Background(#br)Integrative genomics approaches that combine genotyping and transcriptome profiling in segregating populations have been developed to dissect complex traits. The most common approach is to identify genes whose eQTL colocalize with QTL of interest, pro...
作者:Yuna Blum , Rémy Nicolle ...
来源:[J].Nature Communications(IF 10.015), 2018, Vol.9 (1), pp.1-10DOAJ
摘要:Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differin...
作者:Yuna Blum , Laetitia Marisa ...
来源:[J].Cell Reports, 2017, Vol.21 (9), pp.2458-2470DOAJ
摘要:Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) xenografts from either resectable o...

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