全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yukimasa Shiotsu , Taisuke Nakata ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2008, Vol.113 (3), pp.195-201Elsevier
摘要:Abstract(#br)In order to evaluate the importance of estrogen production in tumor and surrounding tissues, we measured mRNA expression levels of 5 enzymes participating to estrogen synthesis in situ and 4 breast cancer-related proteins in 27 pairs of tumor and non-malignant t...
作者:Yukimasa Shiotsu , Shiro Akinaga ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2003, Vol.86 (3), pp.449-454Elsevier
摘要:Abstract(#br)Steroid sulfatase (STS) hydrolyzes inactive estrone sulfate (E1-S) to estrone (E1), while estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to estrogen sulfates. They are considered to play important roles in the regulation of local estrogeni...
作者:Yukimasa Shiotsu , Chikara Murakata ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2003, Vol.86 (3), pp.455-460Elsevier
摘要:Abstract(#br)More than two-thirds of breast cancers occur in post-menopausal women, and depend on the estrogens for their proliferation and survival. For the treatment of estrogen-dependent breast cancers, two major treatment options are now available. One is selective estro...
作者:Yukimasa Shiotsu , Hideyuki Tanaka ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2007, Vol.106 (2), pp.215-227Springer
摘要:Abstract(#br)We screened a series of 17 β -( N -alkylcarbamoyl)-estra-1,3,5(10)trine-3- O -sulfamate derivatives, and describe here a potent and selective steroid sulfatase (STS) inhibitor with antitumor effects in breast cancer models in vitro and in vivo. In biochemical as...
作者:... Shiro Akinaga , Yukimasa Shiotsu , Hitoshi Arai
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2008, Vol.18 (20), pp.5472-5477Elsevier
摘要:Abstract(#br)5-(1,3,4-Oxadiazol-2-yl)pyrimidine derivative 1 was identified as a new class of FLT3 inhibitor from our compound library. With the aim of enhancement of antitumor activity of 2 prepared by minor modification of 1 , structure optimization of side chains at the 2-, 4-...
作者:Yukimasa Shiotsu , Yuichi Ishikawa ...
来源:[J].International Journal of Hematology(IF 1.681), 2010, Vol.92 (4), pp.624-633Springer
摘要:Abstract(#br)Activating mutations of KIT play an important role in the pathophysiology of several human malignancies, including acute myeloid leukemia. Activated KIT kinase is therefore a promising molecular target for the treatment of many malignancies harboring KIT activation. ...
作者:Yukimasa Shiotsu , Hiroaki Mitsuya
来源:[J].International Journal of Oncology(IF 2.657), 2015, Vol.46 (3), pp.963-972Spandidos
摘要:Shikonin (SHK), a natural small agent (MW 288.3), reportedly induces celldeath in various tumor cells. We have found that SHK also exerts potent cytocidaleffects on human multiple myeloma (MM) cells, but its anticancer mechanism inMM cells remains to be elucidated. SHK at 2....

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