全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Tatsuya Sakaguchi , Yuichiro Higashimoto , Sho-ichi Yamagishi
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for athe...
作者:... Eriko Oda , Yuichiro Higashimoto , Sho-ichi Yamagishi
来源:[J].Cardiovascular Diabetology(IF 4.209), 2015, Vol.14 (1)Springer
摘要:Abstract(#br) Background(#br)We have previously shown that serum levels of glyceraldehyde-derived advanced glycation end products (Gly-AGEs) are elevated under oxidative stress and/or diabetic conditions and associated with insulin resistance, endothelial dysfunction and vas...
作者:Yuichiro Higashimoto , Toru Takahashi ...
来源:[J].Analytical Biochemistry(IF 2.582), 2015, Vol.489, pp.50-52Elsevier
摘要:Abstract(#br)We recently reported a novel heme sensor using fluorescently labeled heme oxygenase-1; however, its inherent enzyme activity would be a potential obstacle in quantifying heme in biological samples. Here, we found that mutation of the catalytically important residue, ...
作者:Yuichiro Higashimoto , Takanori Matsui
来源:[J].International Journal of Cardiology(IF 5.509), 2014, Vol.171 (3), pp.443-446Elsevier
摘要:Abstract(#br)Background(#br)Advanced glycation end products (AGE) and their receptor (RAGE) interaction elicit inflammatory and proliferative reactions in arteries, thus playing a role in cardiovascular disease. We have recently found that high-affinity DNA aptamer directed ...
作者:Takanori Matsui , Yuichiro Higashimoto , Sho-ichi Yamagishi
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2014, Vol.443 (3), pp.847-851Elsevier
摘要:Abstract(#br)Pigment epithelium-derived factor (PEDF) has anti-inflammatory and anti-thrombogenic properties both in cell culture and animal models. Although adipose triglyceride lipase (ATGL) and laminin receptor (LR) are two putative receptors for PEDF, which receptor mainly me...
作者:Yuichiro Higashimoto , Kei Fukami
来源:[J].Immunology Letters(IF 2.337), 2015, Vol.167 (2), pp.141-146Elsevier
摘要:Abstract(#br)We have previously found that glyceraldehyde-derived advanced glycation end products (glycer-AGEs) elicit oxidative stress generation and evoke inflammatory and thrombotic reactions through their higher binding affinity to RAGE (receptor for AGEs), thereby playi...
作者:Yuichiro Higashimoto , Takanori Matsui ...
来源:[J].Microvascular Research(IF 2.929), 2013, Vol.90, pp.64-70Elsevier
摘要:Abstract(#br)Advanced glycation end products (AGEs) not only inhibit DNA synthesis of retinal pericytes, but also elicit vascular hyperpermeability, pathological angiogenesis, and thrombogenic reactions by inducing vascular endothelial growth factor (VEGF) and plasminogen ac...
作者:Yuichiro Higashimoto , Junichi Taira
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2013, Vol.441 (2), pp.405-410Elsevier
摘要:Abstract(#br)Pigment epithelium-derived factor (PEDF) exerts atheroprotective effects both in cell culture and animal models through its anti-oxidative and anti-inflammatory properties. Caveolin-1 (Cav), a major protein component of caveolae in endothelial cells (ECs), plays...
作者:Junichi Taira , Yuichiro Higashimoto
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2013, Vol.431 (4), pp.724-728Elsevier
摘要:Abstract(#br)Caveolin-1 is highly expressed in prostate cancer cells, and is implicated in disease progression. Here, we identified protein phosphatase 5 (PP5) as a novel cellular binding partner of caveolin-1 using a pull-down approach in combination with mass spectrometry-...

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