全部文献期刊会议图书|学者科研项目
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作者:Yuan-Zhi Lao , Hong-Sheng Tan ...
来源:[J].Tetrahedron Letters(IF 2.397), 2018
摘要:Abstract(#br)Seven new spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperhenones G–M ( 1 – 7 ), were isolated from the ethyl acetate fraction of Hypericum henryi . The structures of 1 – 6 sharing a common octahydrospiro[cyclohexan-1,5′-indene]-2,4,...
作者:Yuan-Zhi Lao , Dan Zheng ...
来源:[J].Pharmacological Research(IF 4.346), 2019, Vol.147
摘要:Abstract(#br)A global transcriptional regulator, MgrA, was previously identified as a key determinant of virulence in Staphylococcus aureus . An 80% EtOH extract of Uncaria gambier was found to attenuate the virulence of S. aureus via its effects on MgrA. Using bioassay-guid...
作者:... Hua Zhou , Yuan-zhi Lao , Hong-xi Xu
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2020, Vol.41 (5), pp.82-92
摘要:Abstract(#br)Metastasis causes the main lethality in esophageal cancer patient. Garcinol, a natural compound extracted from Gambogic genera , is a histone acetyltransferase (HAT) inhibitor that has shown anticancer activities such as cell cycle arrest and apoptosis induction...
作者:Yuan-Zhi Lao , Hong-Sheng Tan
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.4833-4843
摘要:Abstract(#br)A UPLC-PDA-QTOFMS-guided isolation strategy was employed to screen and track potentially new compounds from Garcinia oblongifolia . As a result, two new prenylated xanthones, oblongixanthones D and E ( 1 – 2 ), six new prenylated benzoylphloroglucinol derivative...
作者:Yuan-Zhi Lao , Li-Jiang Liu ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2008, Vol.369 (4), pp.1007-1011
摘要:Abstract(#br)We have recently reported that bis(7)-tacrine could prevent glutamate-induced neuronal apoptosis through NMDA receptors. In this study, we demonstrated that in cultured rat cortical neurons, bis(7)-tacrine (IC 50 , 0.02 μM) prevented glutamate-induced excitotoxi...
作者:Yuan-zhi Lao , Hong-sheng Tan ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2019, Vol.40 (7), pp.929-937
摘要:Abstract(#br)Lysosomes are the terminal organelles of the autophagic-endocytic pathway and play a key role in the degradation of autophagic contents. We previously reported that a natural compound oblongifolin C (OC) increased the number of autophagosomes and impaired the de...
作者:Yuan-zhi Lao , Song-shu Xiao ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2019, Vol.40 (3), pp.919-928
摘要:Abstract (#br)Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number of natural products display strong antitumor ...
作者:... Hong-sheng Tan , Yuan-zhi Lao , Hong-xi Xu
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2017, Vol.38 (2), pp.252-263
摘要:Abstract(#br)Oblongifolin C (OC) and guttiferone K (GUTK) are two anticancer compounds extracted from Garcinia yunnanensis Hu, but they act by different mechanisms. In this study we investigated whether a combination of OC and GUTK (1:1 molar ratio) could produce synergistic...
作者:Yuan-zhi Lao , Rong Wu ...
来源:[J].Mediators of Inflammation(IF 3.882), 2015, Vol.2015
摘要:Garcinia Linn. plants having rich natural xanthones and benzophenones with anti-inflammatory activity attracted a great deal of attention to discover and develop them as potential drug candidates. Through screening targeting nitric oxide accumulation in stimulated macrophage...

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