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作者:Yuan-Zhi Lao , Lian-Bo Xiao
来源:[J].Molecules(IF 2.428), 2016, Vol.21 (10)DOAJ
摘要:Nujiangexathone A (NJXA), a novel compound derived from Garcinia nujiangensis, has been demonstrated to inhibit the proliferation of several human cancer cell lines. This study is the first to demonstrate the apoptosis inductive activities of NJXA and the possible underlying mech...
作者:... Hua Zhou , Yuan-zhi Lao , Hong-xi Xu
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2020, Vol.41 (5), pp.82-92Springer
摘要:Abstract(#br)Metastasis causes the main lethality in esophageal cancer patient. Garcinol, a natural compound extracted from Gambogic genera , is a histone acetyltransferase (HAT) inhibitor that has shown anticancer activities such as cell cycle arrest and apoptosis induction...
作者:Yuan-Zhi Lao , Hong-Sheng Tan ...
来源:[J].Tetrahedron Letters(IF 2.397), 2018Elsevier
摘要:Abstract(#br)Seven new spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperhenones G–M ( 1 – 7 ), were isolated from the ethyl acetate fraction of Hypericum henryi . The structures of 1 – 6 sharing a common octahydrospiro[cyclohexan-1,5′-indene]-2,4,...
作者:Yuan-Zhi Lao , Dan Zheng ...
来源:[J].Pharmacological Research(IF 4.346), 2019, Vol.147Elsevier
摘要:Abstract(#br)A global transcriptional regulator, MgrA, was previously identified as a key determinant of virulence in Staphylococcus aureus . An 80% EtOH extract of Uncaria gambier was found to attenuate the virulence of S. aureus via its effects on MgrA. Using bioassay-guid...
作者:Yuan-zhi Lao , Rong Wu ...
来源:[J].Mediators of Inflammation(IF 3.882), 2015, Vol.2015Hindawi
摘要:Garcinia Linn. plants having rich natural xanthones and benzophenones with anti-inflammatory activity attracted a great deal of attention to discover and develop them as potential drug candidates. Through screening targeting nitric oxide accumulation in stimulated macrophage...
作者:Yuan-Zhi Lao , Fang Chen ...
来源:[J].Phytochemistry Letters(IF 1.179), 2014, Vol.8, pp.38-40Elsevier
摘要:Abstract(#br)Two new lignans, gymnothelignans V ( 1 ) and W ( 2 ), were isolated from a methanol extraction of Gymnotheca chinensis Decne. Their structures were established on the basis of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited moderate cytotoxicity again...
作者:Yuan-Zhi Lao , Li-Jiang Liu ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2008, Vol.369 (4), pp.1007-1011Elsevier
摘要:Abstract(#br)We have recently reported that bis(7)-tacrine could prevent glutamate-induced neuronal apoptosis through NMDA receptors. In this study, we demonstrated that in cultured rat cortical neurons, bis(7)-tacrine (IC 50 , 0.02 μM) prevented glutamate-induced excitotoxi...
作者:Yuan-zhi Lao , Hua Zhou ...
来源:[J].Frontiers in Oncology, 2019, Vol.9DOAJ
摘要:Non-small-cell lung cancer (NSCLC) is the predominant form of lung cancer, and it is regulated by a complex signal transduction network. Single-agent targeted therapy often results in acquired resistance, which leads to treatment failure. In this study, we demonstrated that a com...
作者:Yuan-Zhi Lao , Lian-Bo Xiao ...
来源:[J].Molecules(IF 2.428), 2016, Vol.21 (10)MDPI
摘要:Nujiangexathone A (NJXA), a novel compound derived from Garcinia nujiangensis, has been demonstrated to inhibit the proliferation of several human cancer cell lines. This study is the first to demonstrate the apoptosis inductive activities of NJXA and the possible underlying mech...
作者:Yuan-Zhi Lao , Wen-Wei Fu ...
来源:[J].Natural Products and Bioprospecting, 2020, Vol.10 (1), pp.1-11Springer
摘要:Abstract(#br)A series of dearomatized isoprenylated acylphloroglucinols derivatives, hyperhenols A–E ( 1 – 5 ), as well as seven known analogues ( 6 – 12 ), were characterized from Hypericum henryi . Their structures were determined by combination of NMR, ECD spectrosco...

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