全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yuan-Jhe Chang , Jian-Lian Chen ...
来源:[J].Molecules(IF 2.428), 2018, Vol.23 (3)DOAJ
摘要:8-Nitroguanine (8-nitroG) is a major mutagenic nucleobase lesion generated by peroxynitrite during inflammation and has been used as a potential biomarker to evaluate inflammation-related carcinogenesis. Here, we present an online solid-phase extraction (SPE) LC-MS/MS method with...
作者:Yuan-Jhe Chang , Ya-Chun Chang ...
来源:[J].Oxidative Medicine and Cellular Longevity(IF 3.393), 2018, Vol.2018Hindawi
摘要:This study is aimed at developing a method that can inhibit resveratrol (Res) degradation in Dulbecco’s modified Eagle medium (DMEM) and at evaluating the effects of Res on the replicative lifespan of Hs68 cells. We hypothesized that Res can extend the lifespan of Hs68 cells...
作者:Yuan-Jhe Chang , Cheng-Chieh Yen ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2019, Vol.143, pp.193-202Elsevier
摘要:Abstract(#br)Determination of the modulation of nitrite and nitrate levels in biological samples usually poses a major challenge, owing to their high background concentrations. To effectively investigate the variation of nitrite/nitrate in vivo , in this study, we developed ...
作者:Yuan-Jhe Chang , Marcus S. Cooke ...
来源:[J].Archives of Toxicology(IF 5.215), 2018, Vol.92 (8), pp.2665-2680Springer
摘要:Abstract(#br)Adductomics is expected to be useful in the characterization of the exposome, which is a new paradigm for studying the sum of environmental causes of diseases. DNA adductomics is emerging as a powerful method for detecting DNA adducts, but reliable assays for it...
作者:... Marcus S. Cooke , Yuan-Jhe Chang , Mu-Rong Chao
来源:[J].Journal of Hazardous Materials(IF 3.925), 2018, Vol.358, pp.397-404Elsevier
摘要:Abstract(#br)Unburnt tobacco and tobacco smoke contain a variety of carcinogens, exposure to which are causally associated with the incidence of several human cancers. Herein, we used isotope-dilution LC–MS/MS for the quantification of alkylated purines in DNA, following in ...
作者:Yuan-Jhe Chang , Bo-Huei Lin
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2016, Vol.93, pp.77-83Elsevier
摘要:Abstract(#br)Urinary tract infections (UTIs) are the most common type of nosocomial infection. Traditionally, the presence of white blood cells and microorganisms in the urine provides objective evidence for UTI diagnosis. Here, we describe the use of liquid chromatography–t...
作者:Yuan-Jhe Chang , Yu-Wen Hsu ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2016, Vol.101, pp.348-355Elsevier
摘要:Abstract(#br)Peroxynitrite is a major oxidizing and nitrating biological agent formed at sites of inflammation. Peroxynitrite can cause DNA damage and is thought to contribute to inflammation-related carcinogenesis. This study describes a sensitive and reliable liquid chroma...
作者:Yuan-Jhe Chang , Mu-Rong Chao ...
来源:[J].Analytical and Bioanalytical Chemistry(IF 3.659), 2014, Vol.406 (9-10), pp.2445-2455Springer
摘要:Abstract(#br)A total sample-preparation and analysis time of 50 min is required for the high-throughput method of hair analysis proposed in this paper. The method is applicable to analysis of drugs commonly used in Asia, and their metabolites—methamphetamine (MA), amphetamin...
作者:Yuan-Jhe Chang , Keh-Liang Lin , Yan-Zin Chang
来源:[J].Clinica Chimica Acta(IF 2.85), 2013, Vol.420, pp.155-159Elsevier
摘要:Abstract(#br)Background(#br)Di-(2-ethylhexyl)phthalate (DEHP) is an endocrine disrupting chemical that is widely used as the major plasticizer for worldwide plastic products. It can cause several toxic effects to human with high dose exposure. In response to the need of huma...
作者:Yuan-Jhe Chang , Keh-Liang Lin
来源:[J].Analytical and Bioanalytical Chemistry(IF 3.659), 2012, Vol.402 (2), pp.851-859Springer
摘要:Abstract(#br)The detection and confirmation of cannabinoids in oral fluid are important in forensic toxicology. Currently, the presence of Δ 9 -tetrahydrocannabinol (THC) is used for the detection of cannabis in oral fluid. A low concentration of 11-nor-9-carboxy-Δ 9 -tetrah...

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