全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... Tim H.-M. Huang , Shu-Huei Hsiao , Yu-Wei Leu
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.494 (3-4), pp.470-476
摘要:Abstract(#br)Negative valine (V) to phenylalanine (F) switch at the Janus kinase (JAK2) 617 codon (V617F) is the dominant driver mutation in patients with myeloproliferative neoplasms (MPNs). JAK2V617F was proved to be sufficient for cell transformation; however, independent...
作者:... Chen-Yu Hsiao , Yu-Wei Leu , Tzu-Hsien Wang
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (12)
摘要:Human mesenchymal stem cells (MSCs) modified by targeting DNA hypermethylation of genes in the Salvador/Warts/Hippo pathway were induced to differentiate into neuronal cells in vitro. The differentiated cells secreted a significant level of brain-derived neurotrophy factor (...
作者:Yu-Wei Leu , Tim H-M Huang ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (6)
摘要:One big limitation of computational tools for analyzing ChIP-seq data is that most of them ignore non-unique tags (NUTs) that match the human genome even though NUTs comprise up to 60% of all raw tags in ChIP-seq data. Effectively utilizing these NUTs would increase the sequencin...
作者:Yu-Wei Leu , Pei-Yi Chu ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2014, Vol.453 (3), pp.338-344
摘要:Abstract(#br)Fetal alcohol syndrome (FAS) is a birth defect due to maternal alcohol consumption during pregnancy. Because mesenchymal stem cells (MSCs) are the main somatic stem cells in adults and may contribute to tissue homeostasis and repair in adulthood, we investigated...
作者:... Tim H.-M. Huang , Yu-Wei Leu , Shu-Huei Hsiao
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2013, Vol.442 (1-2), pp.56-61
摘要:Abstract(#br)Endosulfine alpha (ENSA) is an endogenous ligand of sulfonylurea receptor that was reported to be associated with an ATP-dependent potassium channel that controls insulin release and the onset of type 2 diabetes. ENSA also interacts with microtubule-associated s...
作者:... Shaw-Jenq Tsai , Tim H.-M. Huang , Yu-Wei Leu
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.400 (3), pp.305-312
摘要:Abstract(#br)Epigenetic regulation of gene expression by DNA methylation and histone modification controls cell fate during development and homeostasis in adulthood. Aberrant epigenetic modifications may lead to abnormal development, even diseases. We have found that Trip10 ...
作者:Yu-Wei Leu , Wu-Hsiung Wu ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.402 (2), pp.228-234
摘要:Abstract(#br)DNA methylation is a gene-silencing and host defense system that can down-regulate viral gene expression in mammalian cells. An established targeted DNA methylation method was used to demonstrate that genome-integrated CMV and adenovirus type 5 E1A promoters wer...
作者:... Tim H.-M. Huang , Shu-Huei Hsiao , Yu-Wei Leu
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.422 (4), pp.578-585
摘要:Abstract(#br)Casp8AP2 contains a FLASH functional domain and is critical for the formation of death complex and the relay of death signal into the cells. Genetic defects in Casp8AP2 are associated with several diseases. A CpG island within the Casp8AP2 promoter is differentially ...
作者:Shu-Huei Hsiao , Tim H.-M. Huang , Yu-Wei Leu
来源:[J].Seminars in Cancer Biology(IF 7.436), 2009, Vol.19 (3), pp.198-208
摘要:Abstract(#br)Epigenetic events like DNA methylation are known to regulate gene expression, and dysregulation of these events is associated with neoplastic proliferation. Here, we provide a step-by-step review of the approach that has gradually developed to identify critical DNA m...
作者:... Tim H.-M. Huang , Yu-Wei Leu , Shu-Huei Hsiao
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.425 (2), pp.290-296
摘要:Abstract(#br)Polycomb-group proteins mark specific chromatin conformations in embryonic and somatic stem cells that are critical for maintenance of their “stemness”. These proteins also mark altered chromatin modifications identified in various cancers. In normal differentia...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×