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作者:... Walter M. Holleran , Kyungho Park , Yoshikazu Uchida
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2018Elsevier
摘要:Abstract(#br)The innate immune element, cathelicidin antimicrobial peptide (CAMP), is vital in the formation of the antimicrobial barrier in skin. CAMP production is increased during epidermal differentiation and enriched in the stratum corneum. We recently identified an endoplas...
作者:Yoshikazu Uchida , Kyungho Park ...
来源:[J].The American Journal of Pathology(IF 4.522), 2018, Vol.188 (6), pp.1419-1429Elsevier
摘要:Mutations in several lipid synthetic enzymes that block fatty acid and ceramide production produce autosomal recessive congenital ichthyoses (ARCIs) and associated abnormalities in permeability barrier homeostasis. However, the basis for the phenotype in patients with NIPAL4...
作者:Yoshikazu Uchida , Young il Kim , Kyungho Park
来源:[J].Dermatologica Sinica(IF 0.218), 2015, Vol.33 (2), pp.78-83Elsevier
摘要:Abstract(#br)The skin epidermis is a multipurpose barrier (i.e., against epidermal permeability disruption and oxidative/UV irradiation) as well as a mechanical barrier and antimicrobial barrier, to protect cells/tissues from external perturbants. When there is a normal barrier, ...
作者:... Peter M. Elias , Yoshikazu Uchida , Kyungho Park
来源:[J].Journal of Dermatological Science(IF 3.52), 2015, Vol.79 (3), pp.229-234Elsevier
摘要:Abstract(#br)Background(#br)The ceramide metabolite, sphingosine-1-phosphate (S1P), regulates multiple cellular functions in keratinocytes (KC). We recently discovered that production of a key innate immune element, cathelicidin antimicrobial peptide (CAMP), is stimulated vi...

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