全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yonglan Zhang , Jianhui Liu
来源:[J].Archives of Pharmacal Research(IF 1.538), 2017, Vol.40 (5), pp.571-578Springer
摘要:An large body of evidence indicates that leptin has protective role against Alzheimer’s disease, where it reduces β-amyloid (Aβ) production in both cell culture and animal models. Our previous studies revealed that geniposide could attenuate the production of Aβ1–4...
作者:... Zixuan Liu , Yonglan Zhang , Fei Yin
来源:[J].Indian Journal of Medical Research(IF 2.061), 2015, Vol.142 (2), pp.190-195DOAJ
摘要:Background & objectives: Amyloid β-peptide (Aβ) has been shown to be responsible for senile plaque formation and cell damage in Alzheimer′s disease (AD). This study was aimed to explore the role of natural compound icariin on the aggregation and the cytotoxicity of Aβ i...
作者:Yonglan Zhang , Zixuan Liu
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (10)DOAJ
摘要:Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes of type 2 diabetes mellitus (T2DM). Although the KATP channel-dependent mechanism of GSIS has be...
作者:... Zixuan Liu , Yonglan Zhang , Fei Yin
来源:[J].Indian Journal of Medical Research(IF 2.061), 2015, Vol.142 (2), pp.190-195Wolters Kluwer
摘要:Background & objectives: Amyloid β-peptide (Aβ) has been shown to be responsible for senile plaque formation and cell damage in Alzheimer′s disease (AD). This study was aimed to explore the role of natural compound icariin on the aggregation and the cytotoxicity of Aβ i...
作者:Yonglan Zhang , Fengqing Yang ...
来源:[J].Pharmacognosy Magazine(IF 1.525), 2016, Vol.12 (46), pp.120-127Wolters Kluwer
摘要:Background: Peroxisome proliferator-activated receptors (PPAR)-γ is widely used as an attractive target for the treatment of type 2 diabetes mellitus. Thiazolidinediones, the agonists of PPARγ, has been popularly utilized as insulin sensitizers in the therapy of type 2 diabe...
作者:... Fei Yin , Yonglan Zhang , Jianhui Liu
来源:[J].Journal of Natural Medicines(IF 1.516), 2017, Vol.71 (1), pp.123-130Springer
摘要:Abstract(#br)Our previous work showed that geniposide affected glucose-stimulated insulin secretion (GSIS) via regulating glucose uptake and metabolism in pancreatic β cells; however, the molecular mechanisms remain largely unknown. Substantial evidence suggests that activat...
作者:Yonglan Zhang , Fei Yin ...
来源:[J].Neurochemistry International(IF 2.659), 2015, Vol.89, pp.7-16Elsevier
摘要:Abstract(#br)Our previous studies have shown that geniposide plays an essential role in glucose-stimulated insulin secretion from pancreatic β cells and also antagonizesAβ 1–42 -induced cytotoxicity examined using a primary cortical neuron assay. However, the mechanism by wh...
作者:Yonglan Zhang , Fei Yin ...
来源:[J].Chemical Biology & Drug Design(IF 2.469), 2016, Vol.87 (3), pp.409-418Wiley
摘要:Our previous studies have shown that geniposide plays an essential role in glucose‐stimulated insulin secretion from pancreatic β cells and also regulates the metabolism of Aβ and its deposition in neurons. In this study, we reported that insulin deficiency induced significa...
作者:... Fei Yin , Yonglan Zhang , Jianhui Liu
来源:[J].Cell Biology International(IF 1.64), 2017, Vol.41 (5), pp.544-554Wiley
摘要:Abstract(#br)Our previous works indicated that geniposide could regulate glucose‐stimulated insulin secretion (GSIS), and improved chronic high glucose‐induced dysfunctions in pancreatic β cells, but the molecular mechanisms remain largely unknown. In the present study,...
作者:Yonglan Zhang , Fei Yin ...
来源:[J].Cell Biology International(IF 1.64), 2015, Vol.39 (4), pp.373-378Wiley
摘要:Abstract(#br)Islet amyloid deposition is increasingly seen as a pathogenic feature of type 2 diabetes mellitus (T2DM), with the deposits containing the unique amyloidogenic peptide islet amyloid polypeptide (IAPP, also known as amylin). The fibril precursors of IAPP contribu...

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