全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yong Q Chen , Wei Chen
来源:[J].BMC Systems Biology(IF 2.982), 2015, Vol.9 (1)Springer
摘要:Abstract(#br) Background(#br) Mortierella alpina is an oleaginous fungus used in the industrial scale production of arachidonic acid (ARA). In order to investigate the metabolic characteristics at a systems level and to explore potential strategies for enhanced lipid product...
作者:Yong Q Chen , Lawrence L Rudel ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (5)DOAJ
摘要:Long chain n-3 PUFA have been shown to have chemopreventive properties against breast cancer through various mechanisms. One pathway, studied in human breast cancer cell lines, involves upregulation of the proteoglycan, syndecan-1 (SDC-1) by n-3 PUFA-enriched LDL. Using Fat-...
作者:Yong Q Chen , Wei Chen ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (6)DOAJ
摘要:The oleaginous fungus, Mucor circinelloides, is one of few fungi that produce high amounts of γ-linolenic acid (GLA); however, it usually only produces <25% lipid. Nevertheless, a new strain (WJ11) isolated in this laboratory can produce lipid up to 36% (w/w) cell dry weight...
作者:... Hao Zhang , Yong Q Chen , Wei Chen
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)DOAJ
摘要:Antioxidant activity of lactic acid bacteria is associated with multiple health-protective effects. Traditional indexes of chemical antioxidant activities poorly reflect the antioxidant effects of these bacteria in vivo. Cellular antioxidant activity (CAA) assay was used in this ...
作者:... Hao Zhang , Yong Q Chen , Wei Chen
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (10)DOAJ
摘要:Mucosal vaccine based on lactic acid bacteria is an attractive concept for the prevention and treatment of allergic diseases, but their mechanisms of action in vivo are poorly understood. Therefore, we sought to investigate how recombinant major dust mite allergen Der p2-expressi...
作者:Yong Q Chen , Wei Chen ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (9)DOAJ
摘要:The genome of a high lipid-producing fungus Mucor circinelloides WJ11 (36% w/w lipid, cell dry weight, CDW) was sequenced and compared with that of the low lipid-producing strain, CBS 277.49 (15% w/w lipid, CDW), which had been sequenced by Joint Genome Institute. The WJ11 genome...
作者:... Wei Chen , Zhao He , Yong Q Chen
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.48 (6), pp.2318-2336DOAJ
摘要:Background/Aims: Rapamycin (Rp), the main mammalian target of rapamycin complex inhibitor, is a promising therapeutic agent for breast cancer. However, metabolic disorders and drug resistance reduce its efficacy. Epidemiological, clinical, and experimental studies have demon...
作者:Heidi J Chial , Peter Lenart , Yong Q Chen
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (8)DOAJ
摘要:Human APPL1 and APPL2 are homologous RAB5 effectors whose binding partners include a diverse set of transmembrane receptors, signaling proteins, and phosphoinositides. APPL proteins associate dynamically with endosomal membranes and are proposed to function in endosome-mediated s...

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