全部文献期刊会议图书|学者科研项目
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作者:Yolanda Diebold , Jelena Filipović-Grčić ...
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2020, Vol.576
摘要:Abstract(#br)Inflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation is...
作者:... Irene Molina-Martínez , Rocío Herrero-Vanrell , Yolanda Diebold
来源:[J].Experimental Eye Research(IF 3.026), 2018, Vol.167, pp.118-121
摘要:Abstract(#br)Peptide delivery to and through ocular sites is a growing field of research interest. However, several barriers restrict the permeation and bioavailability of these molecules to target tissues. The main pharmacological barriers of topical administration are the tear ...
作者:... Manuel Martín-Pastor , Yolanda Diebold , Alejandro Sanchez
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2018, Vol.546 (1-2), pp.20-30
摘要:Abstract(#br)We explored the potential of two types of sorbitan ester nanoparticles (SENS) as novel tools for topical ocular drug delivery. The optimized SENS formulation (SENS-OPT) consisted of nanoparticles (NPs) of 170.5 nm, zeta potential +33.9 mV, and cyclosporine loadi...
作者:... Rocío Herrero-Vanrell , Irene T. Molina-Martínez , Yolanda Diebold
来源:[J].Experimental Eye Research(IF 3.026), 2017, Vol.154, pp.79-87
摘要:Abstract(#br)In ocular surface inflammatory diseases, such as dry eye disease, long-term symptom relief requires targeting the inflammation itself rather than treating only the surface-associated dryness with artificial tears. Therefore, we included an anti-inflammatory agent in ...
作者:Jesus Alvarez-Trabado , Yolanda Diebold , Alejandro Sanchez
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2017, Vol.532 (1), pp.204-217
摘要:Abstract(#br)Topically-applied dosage forms, such eye drops, are the most used formulations in the treatment of ocular diseases. Nonetheless, because of the special protection of the eye associated with the ocular surface, drug bioavailability and subsequent therapeutic effi...
作者:... Antonio López-García , Luminita Paraoan , Yolanda Diebold
来源:[J].Experimental Eye Research(IF 3.026), 2015, Vol.134, pp.1-14
摘要:Abstract(#br)Recently, thrombospondin-1 (TSP-1) has been reported to be critical for maintaining a healthy ocular surface. The purpose of the study was to characterize the expression of TSP-1 and of its receptors CD36 and CD47 in corneal and conjunctival epithelial cells and...
作者:... Robin R. Hodges , Yolanda Diebold , Darlene A. Dartt
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.173-185
摘要:Abstract(#br)In the eye, goblet cells responsible for secreting mucins are found in the conjunctiva. When mucin production is not tightly regulated several ocular surface disorders may occur. In this study, the effect of the T helper (Th) 2-type cytokines IL4, IL5, and IL13 on co...
作者:Yolanda Diebold , Li-Li Chen ...
来源:[J].Experimental Eye Research(IF 3.026), 2006, Vol.84 (3), pp.500-512
摘要:Abstract(#br)Sjögren's syndrome is an autoimmune disorder characterized by a progressive, immune-mediated destruction of mucosal tissues such as the lacrimal and salivary glands, leading to ocular and oral dryness. The MRL/MpJ- Fas lpr mouse is one of the animal models used ...

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