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作者:Yeonjung Choi , Kyung Seok Oh ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2013, Vol.23 (7), pp.2134-2139Elsevier
摘要:Abstract(#br)Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl imidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Analysis of the Ligand-lipophilic eff...
作者:Yeonjung Choi , Hyeon Cho ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2434-2439Elsevier
摘要:Abstract(#br)A series of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives were synthesized through discovery strategies for balancing target-based in vitro screening and phenotypic in vivo screening. All the newly synthesized compounds were screened fo...

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