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作者:... Frgala T. , Reynolds C.P. , Yen Y.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.62-68Karger
摘要:Ribonucleotide reductase (RR) is a key regulatory enzyme in the DNA synthesis pathway and is the target of the cancer chemotherapeutic agent hydroxyurea. The study of RR is significantly hindered by the tedious and labor-intensive nature of enzymatic assay. In this report, we pre...
作者:... Liu X. , Qiu W. , Yen Y.
来源:[J].Cytogenetics and Cell Genetics, 2001, Vol.95 (1鈥?), pp.34-42Karger
摘要:In our previous publication it was shown that a Gemcitabine-resistant KBGem clone derived from step-wise exposure to Gemcitabine resulted in overexpression of the human Ribonucleotide Reductase M2 subunit (hRRM2) mRNA and protein (Goan et al., 1999). In this study we confirm...
作者:Zhou B. , Yen Y.
来源:[J].Cytogenetics and Cell Genetics, 2001, Vol.95 (1鈥?), pp.52-59Karger
摘要:Ribonucleotide Reductase (RR) is a rate-limiting enzyme in DNA synthesis and repair consisting of two subunits, M1 and M2. RRM2 plays a role in cell proliferation, tumorgenicity, metastasis and drug resistance. To better understand the regulation of RRM2, we have sequenced t...

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