全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yazan Alwarawrah , Philip Hughes ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many exis...
作者:Yazan Alwarawrah , David R. Loiselle ...
来源:[J].Chemistry & Biology(IF 6.157), 2014, Vol.21 (12), pp.1648-1659Elsevier
摘要:Summary(#br)Inducible Hsp70 (Hsp70i) is overexpressed in a wide spectrum of human tumors, and its expression correlates with metastasis, poor outcomes, and resistance to chemotherapy in patients. Identification of small-molecule inhibitors selective for Hsp70i could provide new t...
作者:Yazan Alwarawrah , Philip Hughes ...
来源:[J].Cell Chemical Biology, 2016, Vol.23 (6), pp.678-688Elsevier
摘要:Summary(#br)Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation is correlated with tumor aggressiveness. The consequences and adaptive responses of a...

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