全部文献期刊会议图书|学者科研项目
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作者:Xiao-Qian Yang , Feng-Hua Zhu ...
来源:[J].Pharmacological Research(IF 4.346), 2018, Vol.129, pp.443-452
摘要:Abstract(#br)DZ2002, a reversible S -adenosyl- l -homocysteine hydrolase (SAHH) inhibitor with immunosuppressive properties and potent therapeutic activity against various autoimmune diseases in mice. The present study was designed to characterize the potential therapeutic e...
作者:Xiu-Deng Zheng , Xiao-Qian Yang , Yi Tao
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (3)
摘要:A hallmark of positive-feedback regulation is bistability, which gives rise to distinct cellular states with high and low expression levels, and that stochasticity in gene expression can cause random transitions between two states, yielding bimodal population distribution (Kaern ...
作者:Xiao-Qian Yang , Feng-Hua Zhu ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)
摘要:BACKGROUND: Artemisinin analogue SM934 was previously reported to possess immunosuppressive properties. The aim of this study was to determine the effects and the underlying mechanisms of SM934 in murine experimental autoimmune encephalomyelitis (EAE). METHODS: Female C57BL/...
作者:Xiao-Qian Yang , Feng-Hua Zhu ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.1141-1146
摘要:Abstract(#br)SM934 is an artemisinin analogue with immunosuppressive properties and potent therapeutic activity against lupus-like diseases in autoimmune mice. In this report, the therapeutic efficacy and underlying mechanisms of SM934 on rheumatoid arthritis (RA) was invest...
作者:Xiao-qian Yang , Feng-hua Zhu ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2018, Vol.39 (10), pp.1633-1644
摘要:Abstract(#br)Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease (IBD) characterized by complicated and relapsing inflammation in the gastrointestinal tract. SM934 is a water-soluble artemisinin analogue that shows anti-inflammatory and immuno-regula...
作者:Xiao-qian Yang , Feng-hua Zhu ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2018, Vol.39 (1), pp.107-116
摘要:Abstract(#br)(5 R )-5-hydroxytriptolide (LLDT-8) is a novel triptolide analog that has been identified as a promising candidate for treating autoimmune diseases and has been shown to be effective in treating murine collagen-induced arthritis and lupus nephritis. In the prese...
作者:Xiao-qian Yang , Feng-hua Zhu ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2015, Vol.36 (2), pp.188-199
摘要:Abstract(#br)Aim:(#br)SM934 is a novel water-soluble artemisinin derivative with immunoregulatory activities that has been used to treat murine lupus nephritis. In the current study, we investigated the effects of SM934 on rat experimental membranous nephropathy. Methods:(#b...
作者:Xiao-qian Yang , Pei-lan He ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2014, Vol.35 (2), pp.219-229
摘要:Abstract(#br)Aim:(#br)To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S -adenosyl- L -homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. Methods:(#br)Female NZB/W F1 mice were treated orally with D...
作者:Xiao-qian Yang , Feng-hua Zhu ...
来源:[J].Acta Pharmacologica Sinica(IF 2.354), 2013, Vol.34 (7), pp.921-929
摘要:Abstract(#br)Aim:(#br)To investigate the effects and underlying mechanisms of 118, a novel derivative of mycophenolic acid, in a murine allogeneic skin graft model. Methods:(#br)Skin grafts were conducted by grafting BALB/c donor tail skin into C57BL/6 skin beds (allograft) ...

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