全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Xiao Ru Huang , Yang Zhang ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (7)DOAJ
摘要:Smad7 has been shown to negatively regulate fibrosis and inflammation, but its role in angiotensin II (Ang II)-induced hypertensive cardiac remodeling remains unknown. Therefore, the present study investigated the role of Smad7 in hypertensive cardiopathy induced by angioten...
作者:... Xiao-ming Meng , Xiao Ru Huang , Hui Yao Lan
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (2)DOAJ
摘要:Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl(4)) and in vitro...
作者:Xiao Ru Huang , Hui Yao Lan ...
来源:[J].Mediators of Inflammation(IF 3.882), 2015, Vol.2015Hindawi
摘要:To expand the armamentarium of treatment for chronic kidney disease (CKD), we explored the utility of boosting endogenously synthesized N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), which is augmented by inhibition of the angiotensin converting enzyme. Male BALB/c mice un...
作者:Xiao Ru Huang , Connie Wun Chun Hui ...
来源:[J].Gastroenterology(IF 12.821), 2001, Vol.121 (3), pp.619-630Elsevier
摘要:Abstract(#br)Background & Aims: Macrophage migration inhibitory factor (MIF) has been shown to play a pivotal role in inflammatory and immune-mediated diseases. This study investigates the role of MIF in gastric inflammation. Methods: Expression of MIF was examined in a rat ...
作者:Xiao Ru Huang , Arthur C.K. Chung ...
来源:[J].The American Journal of Pathology(IF 4.522), 2008, Vol.172 (5), pp.1174-1183Elsevier
摘要:The recent discovery of the angiotensin II (Ang II)-breakdown enzyme, angiotensin I converting enzyme (ACE) 2, suggests the importance of Ang II degradation in hypertension. The present study explored the signaling mechanism by which ACE2 is regulated under hypertensive condition...
作者:Xiao Ru Huang , Jun Xiao ...
来源:[J].The Journal of Pathology(IF 7.585), 2012, Vol.227 (2), pp.175-188Wiley
摘要:Abstract(#br)TGF‐β1 binds receptor II (TβRII) to exert its biological activities but its functional importance in kidney diseases remains largely unclear. In the present study, we hypothesized that TβRII may function to initiate the downstream TGF‐β signalling and deter...
作者:Xiao Ru Huang , Wei Ku Zhang ...
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (3)PLOS
摘要:Increasing evidence shows that TGF-β1 is a key mediator in diabetic nephropathy (DN) and induces renal fibrosis positively by Smad3 but negatively by Smad7. However, treatment of DN by blocking the TGF-β/Smad pathway remains limited. The present study investigated the anti-f...
作者:Xiao Ru Huang , Arthur CK Chung ...
来源:[J].The Journal of Pathology(IF 7.585), 2010, Vol.221 (4), pp.390-401Wiley
摘要:Abstract(#br)Angiotensin II (Ang II) is a key mediator of chronic kidney disease, in which epithelial–mesenchymal transition (EMT) is a critical process mediated by the TGFβ/Smad signalling pathway. The present study examined the specific role of Smads in Ang II‐induced...

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