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作者:... Brigitte Sigal-Zafrani , Anne Vincent-Salomon , Xavier Sastre-Garau
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.7 (4)
摘要:Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the pro...
作者:Xavier Sastre-Garau , Lydia Deschamps ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)
摘要:Melanomas are aggressive skin tumors characterized by high metastatic potential. Our previous results indicate that Natural Killer (NK) cells may control growth of melanoma. The main defect of blood NK cells was a decreased expression of activating NCR1/NKp46 receptor and a posit...
作者:Xavier Sastre-Garau , Marie Rouyer ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-6
摘要:Abstract Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and ...
作者:Xavier Sastre-Garau , Aurélie Berniard ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.9 (1)
摘要:Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. ...
作者:Xavier Sastre-Garau , Yann De Rycke
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (10)
摘要:INTRODUCTION: To decipher the interaction between the molecular subtype classification and the probability of a non-sentinel node metastasis in breast cancer patients with a metastatic sentinel lymph-node, we applied two validated predictors (Tenon Score and MSKCC Nomogram) on tw...
作者:... Bernard Asselain , Xavier Sastre-Garau , Geneviève Almouzni
来源:[J].Molecular Oncology(IF 6.701), 2015, Vol.9 (3), pp.657-674
摘要:Abstract(#br)Background(#br)Breast cancer is a heterogeneous disease with different molecular subtypes that have varying responses to therapy. An ongoing challenge in breast cancer research is to distinguish high-risk patients from good prognosis patients. This is particularly di...
作者:Xavier Sastre-Garau , Philippe Chavrier ...
来源:[J].Breast Cancer Research(IF 5.872), 2016, Vol.18 (1)
摘要:Abstract(#br) Background(#br)Polarity defects are a hallmark of most carcinomas. Cells from invasive micropapillary carcinomas (IMPCs) of the breast are characterized by a striking cell polarity inversion and represent an interesting model for the analysis of polarity abnormaliti...

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