全部文献期刊会议图书|学者科研项目
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作者:Xavier Gallego , Jessica Ruiz-Medina ...
来源:[J].Alcohol(IF 2.255), 2012, Vol.46 (3), pp.205-215
摘要:Abstract(#br)Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic over expression of the alpha 5, alpha 3, bet...
作者:Xavier Gallego , Jill H. Miyamoto ...
来源:[J].Brain Research(IF 2.879), 2013, Vol.1529, pp.1-15
摘要:Abstract(#br)The cluster of human neuronal nicotinic receptor genes ( CHRNA5/A3/B4 ) (15q25.1) has been associated with a variety of smoking and drug-related behaviors, as well as risk for lung cancer. CHRNA3/B4 intergenic single nucleotide polymorphisms (SNPs) rs1948 and rs80234...
作者:Xavier Gallego , Rubén D. Fernández-Montes ...
来源:[J].Drug and Alcohol Dependence(IF 3.141), 2012, Vol.122 (3), pp.247-252
摘要:Abstract(#br)Recent studies have revealed that sequence variants in genes encoding the α3/α5/β4 nicotinic acetylcholine receptor subunits are associated with nicotine dependence. In this study, we evaluated two specific aspects of executive functioning related to drug addict...
作者:Xavier Gallego , Alejandro Amador-Arjona ...
来源:[J].Neurobiology of Disease(IF 5.624), 2006, Vol.24 (2), pp.403-418
摘要:Abstract(#br)Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show incre...
作者:Xavier Gallego , Martin E. Keck ...
来源:[J].Journal of Psychiatric Research(IF 4.066), 2009, Vol.44 (3), pp.157-167
摘要:Abstract(#br)Stressful life events increase the susceptibility for subsequent onset of psychiatric disorders in humans. Previous research has implicated neurotrophins in the onset of some stress-related diseases, such as major depression disorder, post-traumatic stress disor...
作者:Xavier Gallego , Susanna Molas ...
来源:[J].Amino Acids(IF 3.914), 2012, Vol.43 (2), pp.897-909
摘要:Abstract(#br)Nicotinic acetylcholine receptors (nAChRs) are ligand-gated pentameric ion channels that account for the effects of nicotine. Recent genetic studies have highlighted the importance of variants of the CHRNA5/A3/B4 genomic cluster in human nicotine dependence. Amo...
作者:Xavier Gallego , Patricia Murtra ...
来源:[J].Frontiers in Behavioral Neuroscience(IF 4.758), 2010, Vol.3
摘要:Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate dependence, using a transgenic mous...
作者:Xavier Gallego , Ryan J. Cox ...
来源:[J].PLOS ONE(IF 3.73), 2013, Vol.8 (5)
摘要:Common genetic factors strongly contribute to both nicotine, the main addictive component of tobacco, and alcohol use. Several lines of evidence suggest nicotinic acetylcholine receptors as common sites of action for nicotine and alcohol. Specifically, rs1948, a single-nucle...

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