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作者:Wilber Romero-Fernandez , Dasiel O. Borroto-Escuela ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2011, Vol.409 (4), pp.764-768
摘要:Abstract(#br)Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan. FGFR1 homodimers in turn trigger a variety of downstream signaling cascades via autopho...
作者:Wilber Romero-Fernandez , Alexander O. Tarakanov ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.401 (4), pp.605-610
摘要:Abstract(#br)In view of the co-distribution of dopamine D 2L R and 5-hydroxytryptamine 5-HT 2A receptors (D 2L R and 5-HT 2A R, respectively) within inter alia regions of the dorsal and ventral striatum and their role as a target of antipsychotic drugs; in this study we asse...
作者:Wilber Romero-Fernandez , Manuel Narvaez ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2014, Vol.443 (1), pp.278-284
摘要:Abstract(#br)Dopamine D2 L R-serotonin 5-HT2AR heteromers were demonstrated in HEK293 cells after cotransfection of the two receptors and shown to have bidirectional receptor–receptor interactions. In the current study the existence of D2 L -5-HT2A heteroreceptor complexes w...
作者:Wilber Romero-Fernandez , Fidel Corrales ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2013, Vol.435 (1), pp.140-146
摘要:Abstract(#br)Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antagonistic dopamine D2 (D 2 R) and neurotensin 1 (NTS1R) receptor–receptor interactions in the dorsal and ventral striatum indicating a potential role of these rec...
作者:Wilber Romero-Fernandez , Francisco Ciruela ...
来源:[J].Brain Research(IF 2.879), 2012, Vol.1476, pp.119-131
摘要:Abstract(#br)This article is focused on understanding the mechanisms for the interactions between the central catecholamine (CA) and oxytocin (OXY) neurons and their relevance for brain function especially social behaviour in the field of pair bonding. Such a topic is analys...
作者:Wilber Romero-Fernandez , Alexander O. Tarakanov ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2011, Vol.406 (5), pp.687-699
摘要:Abstract(#br)Given that coactivation of adenosine A 2A (A 2A R) and dopamine D 2 (D 2 R) receptors results in the coaggregation, cointernalization, and codesensitization of the A 2A R and D 2 R and the role of scaffolding protein β-arrestin2 in the desensitization, internali...
作者:Wilber Romero-Fernandez , Alexander O. Tarakanov ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.402 (4), pp.801-807
摘要:Abstract(#br)A single serine point mutation (S374A) in the adenosine A 2A receptor (A 2A R) C-terminal tail reduces A 2A R–D 2 R heteromerization and prevents its allosteric modulation of the dopamine D 2 receptor (D 2 R). By means of site directed mutagenesis of the A 2A R ...
作者:Wilber Romero-Fernandez , Manuel Narvaez ...
来源:[J].Journal of Neuroscience Methods(IF 2.114), 2011, Vol.195 (2), pp.161-169
摘要:Abstract(#br)G protein-coupled receptors constitute one of the most important families of membrane receptors through which cells respond to extracellular stimuli. Receptors of this superfamily likely function as signal transduction complexes. The identification and analysis ...
作者:Wilber Romero-Fernandez , Diego Guidolin ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.404 (4), pp.928-934
摘要:Abstract(#br)Dopamine D 2 and D 4 receptors partially codistribute in the dorsal striatum and appear to play a fundamental role in complex behaviors and motor function. The discovery of D 2 R–D 4. x R (D 4.2 R, D 4.4 R or D 4.7 R) heteromers has been made in cellular models ...
作者:Wilber Romero-Fernandez , Giuseppa Mudó ...
来源:[J].Biological Psychiatry(IF 9.247), 2011, Vol.71 (1), pp.84-91
摘要:Background(#br)The hippocampus and its 5-hydroxytryptamine transmission plays an important role in depression related to its involvement in limbic circuit plasticity.(#br)Methods(#br)The analysis was made with bioluminescence resonance energy transfer, co-immunoprecipitation...

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