全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Weigong Ge , Yijun Ding
来源:[J].BMC Bioinformatics(IF 3.024), 2015, Vol.16 (13)Springer
摘要:Abstract(#br) Background(#br)Topic modelling is an active research field in machine learning. While mainly used to build models from unstructured textual data, it offers an effective means of data mining where samples represent documents, and different biological endpoints or omi...
作者:Weigong Ge , Kelci Miclaus ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (9)DOAJ
摘要:During the last several years, high-density genotyping SNP arrays have facilitated genome-wide association studies (GWAS) that successfully identified common genetic variants associated with a variety of phenotypes. However, each of the identified genetic variants only explains a...
作者:... Chandrabose Selvaraj , Weigong Ge , Weida Tong
来源:[J].International Journal of Environmental Research and Public Health(IF 1.998), 2016, Vol.13 (10)DOAJ
摘要:Sunscreen products are predominantly regulated as over-the-counter (OTC) drugs by the US FDA. The “active” ingredients function as ultraviolet filters. Once a sunscreen product is generally recognized as safe and effective (GRASE) via an OTC drug review process, new formulat...
作者:Weigong Ge , Roger Perkins ...
来源:[J].International Journal of Environmental Research and Public Health(IF 1.998), 2016, Vol.13 (4)DOAJ
摘要:Flavonoids are frequently used as dietary supplements in the absence of research evidence regarding health benefits or toxicity. Furthermore, ingested doses could far exceed those received from diet in the course of normal living. Some flavonoids exhibit binding to estrogen ...
作者:Weigong Ge , Leming Shi ...
来源:[J].Journal of Genetics(IF 0.876), 2010, Vol.89 (1), pp.55-64Springer
摘要:Abstract(#br)Genome-wide association studies (GWAS) examine the entire human genome with the goal of identifying genetic variants (usually single nucleotide polymorphisms (SNPs)) that are associated with phenotypic traits such as disease status and drug response. The discordance ...
作者:Weigong Ge , Laura K. Schnackenberg ...
来源:[J].Molecules(IF 2.428), 2012, Vol.17 (3), pp.3383-3406DOAJ
摘要:An interagency collaboration was established to model chemical interactions that may cause adverse health effects when an exposure to a mixture of chemicals occurs. Many of these chemicals—drugs, pesticides, and environmental pollutants—interact at the level of metabolic bio...
作者:Weigong Ge , Laura K. Schnackenberg ...
来源:[J].Molecules(IF 2.428), 2012, Vol.17 (3), pp.3407-3460DOAJ
摘要:Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs. Because many of the drugs are bio-transformed by cytochro...
作者:Weigong Ge , Lei Guo ...
来源:[J].Chemico-Biological Interactions(IF 2.967), 2016, Vol.255, pp.45-54Elsevier
摘要:Abstract(#br)Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog...
作者:Weigong Ge , Weida Tong
来源:[J].Environment International(IF 6.248), 2016, Vol.89-90, pp.81-92Elsevier
摘要:Abstract(#br)Background(#br)ToxCast data have been used to develop models for predicting in vivo toxicity. To predict the in vivo toxicity of a new chemical using a ToxCast data based model, its ToxCast bioactivity data are needed but not normally available. The capability of pre...
作者:Weigong Ge , Lei Guo ...
来源:[J].Chemico-Biological Interactions(IF 2.967), 2016, Vol.255, pp.45-54Elsevier
摘要:Abstract(#br)Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog...

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