全部文献期刊会议图书|学者科研项目
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作者:... Shraddha Thakkar , Weida Tong , Nicholas Petrick
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (14)
摘要:Recent breakthroughs in molecular biology and next generation sequencing technologies have led to the expenential growh of the sequence databases. Researchrs use BLAST for processing these sequences. However traditional software parallelization techniques (threads, message passin...
作者:Weida Tong , Lawrence Lesko
来源:[J].Drug Discovery Today(IF 6.551), 2020
摘要:Pharmacogenomics (PGx), studying the relationship between drug response and genetic makeup of an individual, is accelerating advances in precision medicine. The FDA includes PGx information in the labeling of approved drugs to better inform on their safety and effectiveness....
作者:Weida Tong , Leming Shi ...
来源:[J].Regulatory Toxicology and Pharmacology(IF 2.132), 2020, Vol.112
摘要:Abstract(#br)The use of various omics techniques for scientific research is increasing. While toxicogenomics studies have already produced substantial data on diverse omics platforms, to date there has been little routine application in regulatory toxicology. This is despite the ...
作者:... Leihong Wu , Ruth Roberts , Weida Tong
来源:[J].Drug Discovery Today(IF 6.551), 2020, Vol.25 (1), pp.201-208
摘要:Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed with known DILI severity and toxicity. We aug...
作者:... Ruili Huang , Ruth Roberts , Weida Tong
来源:[J].Trends in Pharmacological Sciences(IF 9.25), 2018
摘要:Toxicogenomics (TGx) has contributed significantly to toxicology and now has great potential to support moves towards animal-free approaches in regulatory decision making. Here, we discuss in vitro TGx systems and their potential impact on risk assessment. We raise awareness of t...
作者:... Liyuan Zhu , Ruth Roberts , Weida Tong
来源:[J].Trends in Genetics(IF 9.772), 2019, Vol.35 (11), pp.852-867
摘要:Next-generation sequencing (NGS) technologies have changed the landscape of genetic testing in rare diseases. However, the rapid evolution of NGS technologies has outpaced its clinical adoption. Here, we re-evaluate the critical steps in the clinical application of NGS-based...
作者:... Valerio Maggio , Weida Tong , Joshua Xu
来源:[J].Computers and Electronics in Agriculture(IF 1.766), 2019, Vol.166
摘要:Abstract(#br)Insect pests are often associated with food contamination and public health risks. Accurate and timely species-specific identification of pests is a key step to scale impacts, trace back the contamination process and promptly set intervention measures, which usually ...
作者:Weida Tong , Menglong Li
来源:[J].Drug Discovery Today(IF 6.551), 2018
摘要:Drug-induced rhabdomyolysis (DIR) is an idiosyncratic and fatal adverse drug reaction (ADR) characterized in severe muscle injuries accompanied by multiple-organ failure. Limited knowledge regarding the pathophysiology of rhabdomyolysis is the main obstacle to developing early bi...
作者:Weida Tong , Dianke Yu
来源:[J].Biochemical Pharmacology(IF 4.576), 2017, Vol.145, pp.178-191
摘要:Abstract(#br)Cytochrome P450 1A2 (CYP1A2) is one of the most abundant and important drug metabolizing enzymes in human liver. However, little is known about the post-transcriptional regulation of CYP1A2, especially the mechanisms involving microRNAs (miRNAs). This study appl...

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