全部文献期刊会议图书|学者科研项目
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作者:Wadad Saba , Emilie Brun ...
来源:[J].Toxicology Letters(IF 3.145), 2017, Vol.265, pp.61-69
摘要:Abstract(#br)The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO 2 NPs toxicokinetics ...
作者:Wadad Saba , Raphaël Boisgard ...
来源:[J].Drug and Alcohol Dependence(IF 3.141), 2017, Vol.170, pp.43-50
摘要:Abstract(#br)Introduction(#br)A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine...
作者:... Bertrand Kuhnast , Wadad Saba , Nicolas Tournier
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2016, Vol.91, pp.98-104
摘要:Abstract(#br)Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro . Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available ( i.e. marketed) P-gp inhi...
作者:Wadad Saba , Amie K. Lund ...
来源:[J].Scientific Reports(IF 2.927), 2017, Vol.7 (Suppl), pp.1769-1780
摘要:Abstract(#br)Notwithstanding potential neurotoxicity of inhaled titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood-brain barrier (BBB) function remain poorly characterized. To improve risk assessment, we need to evaluate the im...
作者:Wadad Saba , Marie-Anne Peyronneau ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (2), pp.227-233
摘要:Abstract(#br)Background(#br)LBT-999 (E)- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane is a dopamine transporter (DAT) ligand. [ 18 F]LBT-999 was first labelled with carbon-11; we will now describe its in vivo behaviour in comparison to that of [ 11 C]LBT-9...
作者:Wadad Saba , Sébastien Goutal ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2013, Vol.40 (7), pp.887-895
摘要:Abstract(#br)Introduction(#br)[ 18 F]Fallypride, a fluorinated and substituted benzamide with high affinity for D 2 /D 3 receptors, is a useful PET radioligand for the study of striatal/extrastriatal areas. Since [ 18 F]fallypride is extensively metabolized in vivo and since...
作者:Wadad Saba , Frédéric Dollé ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (3), pp.347-359
摘要:Abstract(#br)Introduction(#br)LBT-999, ( E )- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane, has been developed for PET imaging of the dopamine transporter. [ 18 F]LBT-999 PET studies in baboons showed a lower brain uptake than [ 11 C]LBT-999 and a high bon...
作者:Wadad Saba , Héric Valette ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2006, Vol.14 (11), pp.3848-3858
摘要:Abstract(#br)FPhEP ( 1 , (+/−)-2- exo -(2′-fluoro-3′-phenyl-pyridin-5′-yl)-7-azabicyclo[2.2.1]heptane) belongs to a recently described novel series of 3′-phenyl analogues of epibatidine, which not only possess subnanomolar affinity and high selectivity for brain α4...

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