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作者:Vojtěch Adam , Zbyněk Heger ...
来源:[J].Monatshefte für Chemie - Chemical Monthly(IF 1.629), 2017, Vol.148 (11), pp.1983-1991
摘要:Ellipticine is an anticancer agent that forms covalent DNA adducts after enzymatic activation by cytochrome P450 (CYP) enzymes, mainly by CYP3A4. This process is one of the most important ellipticine DNA-damaging mechanisms for its antitumor action. Here, we investigated the...
作者:Vojtěch Adam , Tomáš Eckschlager ...
来源:[J].Environmental Toxicology and Pharmacology(IF 2.005), 2020, Vol.74
摘要:Abstract(#br)We studied the in vitro metabolism of the anti-thyroid-cancer drug vandetanib in a rat animal model and demonstrated that N -desmethylvandetanib and vandetanib N -oxide are formed by NADPH- or NADH-mediated reactions catalyzed by rat hepatic microsomes and pure biotr...
作者:Vojtěch Adam , Tomáš Eckschlager ...
来源:[J].Toxicology(IF 4.017), 2019, Vol.419, pp.40-54
摘要:Abstract(#br)Although ellipticine (Elli) is an efficient anticancer agent, it exerts several adverse effects. One approach to decrease the adverse effects of drugs is their encapsulation inside a suitable nanocarrier, allowing targeted delivery to tumour tissue whereas avoiding h...
作者:... Pavel Kopel , Vojtěch Adam , Halina Milnerowicz
来源:[J].Colloids and Surfaces B: Biointerfaces(IF 3.554), 2017, Vol.160, pp.381-389
摘要:Abstract(#br)Thanks to quantum dots’ (QDs) properties, they can be used as selective and sensitive biomarkers in molecular imaging. In a previous paper, we confirmed the possibility of interaction between mercaptosuccinic acid-capped cadmium telluride QDs (MSA-CdTe) and huma...
作者:... Veronika Solčány , Martina Vršanská , Vojtěch Adam
来源:[J].Chemosphere(IF 3.137), 2018, Vol.202, pp.694-707
摘要:Abstract(#br)Ligninolytic enzymes from white-rot fungi are widely used in biotechnological processes. However, the application of these enzymes as free enzymes is limited due to their instability and lack of reusability. Enzyme stabilization is therefore a major challenge in bioc...
作者:Vojtěch Adam , Jan Přibyl
来源:[J].Sensors(IF 1.953), 2019, Vol.19 (13)
摘要:The inhibition effect of the selected heavy metals (Ag+, Cd2+, Cu2+, and Hg2+) on glucose oxidase (GOx) enzyme from Aspergillus niger (EC 1.1.3.4.) was studied using a new amperometric biosensor with an electrochemical transducer based on a glassy carbon electrode (GCE) cove...
作者:Vojtěch Adam , Tomáš Eckschlager ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2019, Vol.20 (14)
摘要:The metabolism of vandetanib, a tyrosine kinase inhibitor used for treatment of symptomatic/progressive medullary thyroid cancer, was studied using human hepatic microsomes, recombinant cytochromes P450 (CYPs) and flavin-containing monooxygenases (FMOs). The role of CYPs and FMOs...
作者:... Jindřich Kynický , Martin Brtnický , Vojtěch Adam
来源:[J].Waste Management(IF 2.485), 2016
摘要:Abstract(#br)An investigation was carried out on the effect of inoculation methods on the compost of an organic fraction of municipal solid waste. Three types of white-rot fungi ( Phanerochaete chrysosporium , Trametes versicolor and Fomes fomentarius ), and a consortium of these...

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