全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Vladimir Burmistrov , Christophe Morisseau ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2020, Vol.30 (3)Elsevier
摘要:Abstract(#br)A series of inhibitors of the soluble epoxide hydrolase (sEH) containing imidazolidine-2,4,5-trione or pirimidine-2,4,6-trione has been synthesized. Inhibition potency of the described compounds ranges from 8.4 μM to 0.4 nM. The tested compounds possess higher w...
作者:Vladimir Burmistrov , Christophe Morisseau ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018, Vol.28 (13), pp.2302-2313Elsevier
摘要:Abstract(#br)A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] ( 6f ) was found to...
作者:Vladimir Burmistrov , Christophe Morisseau ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2018, Vol.76, pp.510-527Elsevier
摘要:Abstract(#br)Adamantyl groups are widely used in medicinal chemistry. However, metabolism limits their usage. Herein, we report the first systematic study of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups ...
作者:Vladimir Burmistrov , Christophe Morisseau ...
来源:[J].Journal of Fluorine Chemistry(IF 1.939), 2019, Vol.220, pp.48-53Elsevier
摘要:Abstract(#br)A series of soluble epoxide hydrolase (sEH) inhibitors containing 2-fluorophenyl fragment was developed. Inhibition potency of the described compounds ranges from 0.7 to 630.9 nM. 1-(Adamantan-1-ylmethyl)-3-(2-fluorophenyl) urea ( 3b , IC 50 = 0.7 nM) and 1-(adamanta...
作者:Vladimir Burmistrov , Christophe Morisseau ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2015, Vol.25 (23), pp.5514-5519Elsevier
摘要:Abstract(#br)Adamantyl ureas are good soluble epoxide hydrolase (sEH) inhibitors; however they have limited solubility and rapid metabolism, thus limiting their usefulness in some therapeutic indications. Herein, we test the hypothesis that nodal substitution on the adamantane wi...
作者:Vladimir Burmistrov , Christophe Morisseau ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (9), pp.2193-2197Elsevier
摘要:Abstract(#br)A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] ( 3b ) was found to be a potent sl...
作者:Gennady M. Butov , Vladimir Burmistrov , Karim R. Saad
来源:[J].Modern Organic Chemistry Research, 2017, Vol.2 (3)Isaac
摘要:This manuscript deals with the synthesis of various Adamantane derivatives as objects of supramolecular chemistry, in particular, supramolecular Cyclodextrine polymers (SCP) and Rotaxanes. One of the structural elements of the SCP and Rotaxanes are linear molecules modified ...

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