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作者:... Myriam Le Roch , Vera L. Eifler-Lima , Michèle David
来源:[J].Tetrahedron Letters(IF 2.397), 2008, Vol.49 (47), pp.6607-6609
摘要:Abstract(#br)Kavalactone derivatives were synthesized using a Heck reaction of the 4-methoxy-6-vinyl-5,6-dihydropyran-2-one with aryl iodides. The Suzuki–Miyaura reaction of an aryl boronic acid and ( Z )-4-methoxy-6-(2-iodovinyl)-5,6-dihydropyran-2-one has also been success...
作者:Vera L. Eifler-Lima , Gilsane L. von Poser
来源:[J].Current Medicinal Chemistry(IF 4.07), 2015, Vol.22 (11), pp.1312-1323
摘要:Imidazoles and benzimidazoles are privileged heterocyclic bioactive compounds used withsuccess in the clinical practice of innumerous diseases. Although there are many advancements in cancertherapy, microtubules remain as one of the few macromolecular targets validated for planni...
作者:Vera L. Eifler-Lima , Gilsane L. von Poser
来源:[J].Current Medicinal Chemistry(IF 4.07), 2015, Vol.22 (11), pp.1312-1323
摘要:Imidazoles and benzimidazoles are privileged heterocyclic bioactive compounds used withsuccess in the clinical practice of innumerous diseases. Although there are many advancements in cancertherapy, microtubules remain as one of the few macromolecular targets validated for planni...
作者:... mulo F. S. Canto , Vera L. Eifler-Lima , Teresa Dalla Costa
来源:[J].Xenobiotica(IF 1.984), 2013, Vol.44 (3), pp.254-263
摘要:Abstract 1. The present work investigated the pharmacokinetic and tissue distribution as well as acute toxicity of a new chemical entity (NCE), the anticancer candidate LaSOM 65 in Wistar rats. 2. LaSOM 65 pharmacokinetics was investigated after intravenous (i.v., 1 mg/kg)...
作者:... Mariane Pazinatto , Eduardo R. de Oliveira , Vera L. Eifler-Lima
来源:[J].Letters in Organic Chemistry(IF 0.667), 2008, Vol.6 (1), pp.90-93
摘要:A new solid-phase synthesis of pyrrolizidine nucleus related to hyacinthacine core using L-proline as the starting material is reported. The final step is a new approach with a cyclization-cleave strategy, which releases the product from the resin in good yields under Baylis-Hill...
作者:Vera L. Eifler-Lima , Valdir Cechinel Filho
来源:[J].Pharmacological Reports(IF 1.965), 2012, Vol.64 (6), pp.1419-1426
摘要:Abstract(#br)Background(#br)Kavalactones are pharmacologically active compounds present in preparations of the root trunk of Piper methysticum Forst, known as kava. This work describes the analgesic activity of some synthesized analogues of synthetic kavain, which is the main com...
作者:... Vinícius B. da Silva , Vera L. Eifler-Lima , Daniel F. Kawano
来源:[J].Current Drug Discovery Technologies, 2017, Vol.14 (1), pp.8-24
摘要:Background: Guanine phosphoribosyltransferase (GPRT) is a very attractivetarget for the development of new drugs against G. lamblia because of its critical role inthe synthesis of DNA and RNA. Herein we report the use of in silico approaches toidentify potential G. lamblia GPRT i...

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