全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Tosso Leeb , Vidhya Jagannathan
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:Lipopolysaccharide (endotoxin, LPS) is a strong inducer of the innate immune response. It is widespread in our environment, e.g. in house dust and contributes to asthma. Compared to humans, horses are even more sensitive to LPS. However, data on LPS effects on the equine transcri...
作者:Tosso Leeb , G. Diane Shelton ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:Many inherited polyneuropathies (PN) observed in dogs have clinical similarities to the genetically heterogeneous group of Charcot-Marie-Tooth (CMT) peripheral neuropathies in humans. The canine disorders collectively show a variable expression of progressive clinical signs and a...
作者:Tosso Leeb , Gerli Pielberg ...
来源:[J].BMC Genetics(IF 2.808), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously identified a ~1.5 Mb locus on canine chromosome 27 associated w...
作者:... Kaspar Matiasek , Kai Rentmeister , Tosso Leeb
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (2)DOAJ
摘要:Dandy-Walker-like malformation (DWLM) is the result of aberrant brain development and mainly characterized by cerebellar hypoplasia. DWLM affected dogs display a non-progressive cerebellar ataxia. Several DWLM cases were recently observed in the Eurasier dog breed, which strongly...
作者:... Katriina Tiira , Hannes Lohi , Tosso Leeb
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (3)DOAJ
摘要:We describe a mild form of disproportionate dwarfism in Labrador Retrievers, which is not associated with any obvious health problems such as secondary arthrosis. We designate this phenotype as skeletal dysplasia 2 (SD2). It is inherited as a monogenic autosomal recessive trait w...
作者:... Eliane Marti , Tosso Leeb , Vincent Gerber
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (8)DOAJ
摘要:Recurrent airway obstruction (RAO) is a common and potentially debilitating lower airway disease in horses, which shares many similarities with human asthma. In susceptible horses RAO exacerbation is caused by environmental allergens and irritants present in hay dust. The objecti...
作者:Tosso Leeb , Åke Hedhammar ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)DOAJ
摘要:Immunoglobulin A deficiency (IgAD) is the most common primary immune deficiency disorder in both humans and dogs, characterized by recurrent mucosal tract infections and a predisposition for allergic and other immune mediated diseases. In several dog breeds, low IgA levels have b...
作者:... Anina Bauer , Vidhya Jagannathan , Tosso Leeb
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.12 (10)DOAJ
摘要:We investigated a German Spitz family where the mating of a black male to a white female had yielded three puppies with an unexpected light brown coat color, lightly pigmented lips and noses, and blue eyes. Combined linkage and homozygosity analysis based on a fully penetrant mon...
作者:... Birgit Gredler , Johann Sölkner , Tosso Leeb
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (4)DOAJ
摘要:Tyrolean Grey cattle represent a local breed with a population size of ∼5000 registered cows. In 2003, a previously unknown neurological disorder was recognized in Tyrolean Grey cattle. The clinical signs of the disorder are similar to those of bovine progressive degenerativ...

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