全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Toshiko Tanaka , Stefania Bandinelli ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.6 (9)DOAJ
摘要:Genome-wide association studies (GWAS) are a valuable approach to understanding the genetic basis of complex traits. One of the challenges of GWAS is the translation of genetic association results into biological hypotheses suitable for further investigation in the laboratory. To...
作者:Toshiko Tanaka , Stella Trompet ...
来源:[J].PLoS Genetics(IF 8.694), 2017, Vol.9 (2)DOAJ
摘要:Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associate...
作者:Toshiko Tanaka , Devin Absher ...
来源:[J].PLoS Genetics(IF 8.694), 2009, Vol.5 (10)DOAJ
摘要:Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We sequentially used transcriptional profiling and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for assoc...
作者:Toshiko Tanaka , Frank J A van Rooij ...
来源:[J].PLoS Genetics(IF 8.694), 2011, Vol.7 (6)DOAJ
摘要:White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell...
作者:Toshiko Tanaka , Zoltán Kutalik ...
来源:[J].PLoS Genetics(IF 8.694), 2010, Vol.6 (7)DOAJ
摘要:Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results from a genome-wide association study of serum calcium, integr...
作者:Toshiko Tanaka , Mar Matarin ...
来源:[J].PLoS Genetics(IF 8.517), 2009, Vol.5 (3)DOAJ
摘要:This research investigates the influence of demographic factors on human genetic sub-structure. In our discovery cohort, we show significant demographic trends for decreasing autozygosity associated with population variation in chronological age. Autozygosity, the genomic signatu...
作者:Hiroaki Sato , Toshiko Tanaka , Kentaro Kasai
来源:[J].Alcohol(IF 2.255), 2013, Vol.47 (1), pp.47-52Elsevier
摘要:Abstract(#br)Alcohol intoxication can exacerbate hemodynamic instability following hemorrhagic shock. Impairment of hormonal, neurohumoral, and immune responses can contribute to such instability; however, the relationship between blood alcohol levels and the progression of ...

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