全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Masahiro Yamasaki , Toshihiro Ohba , Noriko Takahashi
来源:[J].BBA - General Subjects(IF 3.848), 2017, Vol.1861 (2), pp.276-285Elsevier
摘要:Abstract(#br)Background(#br)Activation of protein kinase A (PKA) occurs during retinoic acid (RA)-induced granulocytic differentiation of human promyelocytic leukemia HL60 cells. It is known that the RIIα regulatory subunit of PKA, is modified by RA (retinoylated) in the ear...
作者:Toshihiro Ohba , Masahiko Imai ...
来源:[J].BBA - Molecular and Cell Biology of Lipids(IF 4.134), 2016, Vol.1861 (12), pp.2011-2019Elsevier
摘要:Abstract(#br)Retinoic acid (RA) has a variety of biological effects in mammalian cells and tissues. It is well known that RA induces differentiation of human acute promyelocytic leukemia (APL) HL60 cells, fresh human APL cells, and clinical remission in patients with APL. Re...
作者:Toshihiro Ohba , Takayasu Yamauch ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2006, Vol.15 (2), pp.847-853Elsevier
摘要:Abstract(#br)Novel aminophenol analogues were synthesized based on the structure of fenretinide ( N -(4-hydroxyphenyl)retinamide, 5 ), which is a potent anticancer agent. Our findings showed that the anticancer activities of 5 were due to the side chain attached to the aminopheno...
作者:Toshihiro Ohba , Takayasu Yamauchi
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2006, Vol.14 (17), pp.6089-6096Elsevier
摘要:Abstract(#br)Novel compounds were designed based on fenretinide, N -(4-hydroxyphenyl)retinamide ( 2 ), which is a synthetic amide of all- trans -retinoic acid ( 1 ) that is a potent antioxidant and anticancer agent. Our recent findings indicated that antioxidant and anticancer ac...
作者:Noriko Takahashi , Toshio Honda , Toshihiro Ohba
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2005, Vol.14 (2), pp.409-417Elsevier
摘要:Abstract(#br)A series of p -alkylaminophenols including 3 , p -butylaminophenol; 4 , p -hexylaminophenol; 5 , p -octylaminophenol; and 6 , N -( p -methoxybenzyl)aminophenol were synthesized based on the structure of fenretinide, N -(4-hydroxyphenyl)retinamide ( 1 ). This latter a...
作者:... Katsuhiko Takahashi , Toshihiro Ohba , Masue Imaizumi
来源:[J].Cancer Letters(IF 4.258), 2010, Vol.297 (2), pp.252-258Elsevier
摘要:Abstract(#br)Retinoic acid (RA) is a chemotherapeutic agent used to induce neuronal cellular differentiation of neuroblastoma. However, because treatment with RA is associated with the side-effect of nyctalopia, efforts have been underway to identify new compounds that could pote...

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