全部文献期刊会议图书|学者科研项目
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作者:Toru Kawada , Can Zheng ...
来源:[J].BMC Anesthesiology(IF 1.188), 2017, Vol.17 (1)
摘要:Hemodynamic resuscitation in septic shock requires aggressive fluid replacement and appropriate use of vasopressors to optimize arterial pressure (AP) and cardiac output (CO). Because responses to these drugs vary between patients and within patient over time, strict monitoring o...
作者:Toru Kawada , Yusuke Sata ...
来源:[J].The Journal of Physiological Sciences(IF 1.089), 2017, Vol.67 (5), pp.587-593
摘要:This study examined the mechanism of release of endogenous acetylcholine (ACh) in rabbit renal cortex by applying a microdialysis technique. In anesthetized rabbits, a microdialysis probe was implanted into the renal cortex and perfused with Ringer’s solution containing high...
作者:Toru Kawada , Meihua Li ...
来源:[J].Heart and Vessels(IF 2.126), 2017, Vol.32 (4), pp.484-494
摘要:Ivabradine, a bradycardic agent, has been shown to stably reduce patient’s heart rate (HR) in the setting of acute cardiac care. However, an association between atrial fibrillation (AF) risk and acute ivabradine treatment remains a controversial clinical issue, and has not b...
作者:Toru Kawada , Yusuke Sata ...
来源:[J].Autonomic Neuroscience: Basic and Clinical(IF 1.846), 2020, Vol.225
摘要:Abstract(#br)Cardiac microdialysis allows the assessment of cardiac efferent vagal nerve activity from myocardial interstitial acetylcholine (ACh) levels with minimal influence on the neural control of the heart; however, a total picture of the baroreflex-mediated myocardial...
作者:... Takuya Nishikawa , Toru Kawada , Masaru Sugimachi
来源:[J].Journal of Biomechanics(IF 2.716), 2020
摘要:Abstract(#br)Pressure wave reflection is associated with cardiovascular risk. The conceptual distance to a theoretical major reflection site, termed effective reflection distance (ERD), has been associated with aging and augmentation index (AIx) clinically. However, it remains un...
作者:Toru Kawada , Masashi Inagaki ...
来源:[J].The Journal of Physiological Sciences(IF 1.089), 2020, Vol.70 (1), pp.891-975
摘要:Abstract(#br)Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective effects of donepezil, however, remain totally unknown. To elucidate potential mecha...
作者:Toru Kawada , Yohsuke Hayama ...
来源:[J].Life Sciences(IF 2.555), 2019, Vol.219, pp.144-151
摘要:Abstract(#br)Aims(#br)Rilmenidine and moxonidine are centrally acting antihypertensive agents that are more selective for I 1 -imidazoline receptors than for α 2 -adrenergic receptors. Moxonidine previously showed a peripheral vasoconstrictive effect stronger than generally ...
作者:Toru Kawada , Tsuyoshi Akiyama ...
来源:[J].Autonomic Neuroscience: Basic and Clinical(IF 1.846), 2017
摘要:Abstract(#br)Desipramine (DMI) is a blocker of neuronal norepinephrine (NE) uptake transporter. Although intravenous DMI has been shown to cause centrally-mediated sympathoinhibition and peripheral NE accumulation, its parasympathetic effect remains to be elucidated. We hypo...
作者:Toru Kawada , Tsuyoshi Akiyama ...
来源:[J].Autonomic Neuroscience: Basic and Clinical(IF 1.846), 2018
摘要:Abstract(#br)To elucidate the abnormality of cardiac vagal control in streptozotocin-induced type 1 diabetic rats, we measured left ventricular myocardial interstitial acetylcholine (ACh) release in response to α 2 -adrenergic stimulation as an index of in vivo cardiac vagal...
作者:Toru Kawada , Takashi Sonobe ...
来源:[J].Autonomic Neuroscience: Basic and Clinical(IF 1.846), 2019, Vol.218, pp.25-30
摘要:Abstract(#br)Complex interactions are known to occur between the sympathetic and parasympathetic controls of the heart. Although sympathetic nerve stimulation (SNS) usually augments the heart rate (HR) response to vagal nerve stimulation (VNS), exogenously administered norep...

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