全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Nicholas T. Funderburg , Timothy A. Haystead , Jesse J. Kwiek
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many exis...
作者:Timothy A. Haystead , Natasha E. Zachara ...
来源:[J].Cell Reports, 2019, Vol.26 (5), pp.1344-1356.e5Elsevier
摘要:Summary(#br)The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this process occurs abruptly or gr...
作者:Timothy A. Haystead , Soumya Daturpalli ...
来源:[J].Cell Reports, 2015, Vol.12 (6), pp.1006-1018Elsevier
摘要:Summary(#br)The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity, tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms d...
作者:Timothy A. Haystead , Gennady Bratslavsky ...
来源:[J].Cell Reports, 2017, Vol.21 (7), pp.1883-1895Elsevier
摘要:Summary(#br)The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications ...
作者:Timothy A. Haystead , Gennady Bratslavsky ...
来源:[J].Cell Reports, 2017, Vol.21 (7), pp.1883-1895DOAJ
摘要:Summary: The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications als...
作者:... Paul R. Graves , Timothy A. Haystead , Klaus D. Linse
来源:[J].Molecular Microbiology(IF 4.961), 2007, Vol.63 (3), pp.629-643Wiley
摘要:Summary(#br)Clostridium taeniosporum spores have about 12 large, flat, ribbon‐like appendages attached through a common trunk at one spore pole to a previously unknown surface layer outside the coat that is proposed to be called the ‘encasement’. Appendages are about 4....
作者:... Donald P. McDonnell , Thomas Ribar , Timothy A. Haystead
来源:[J].Journal of Biological Chemistry(IF 4.651), 2015, Vol.290 (29), pp.17985-17998Duke University Press
摘要:Pregnancy promotes physiological adaptations throughout the body, mediated by the female sex hormones progesterone and estrogen. Changes in the metabolic properties of skeletal muscle enable the female body to cope with the physiological challenges of pregnancy and may also ...
作者:Nisha Philip , Timothy A. Haystead
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2007, Vol.104 (19), pp.7845-7850JSTOR
摘要:Protein kinases are generally recognized as attractive drug targets to treat a variety of human diseases. Recent analysis of the Plasmodium falciparum kinome identified several kinases that are entirely unique to Plasmodium species. The specific functions and targets of most...

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