全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Mike Groaning , Wolfgang A. Weber , Thomas Reiner
来源:[J].Molecular Imaging and Biology(IF 3.095), 2017, Vol.19 (5), pp.754-761Springer
摘要:The folate receptor (FR) has emerged as an interesting diagnostic and therapeutic drug target with many potential applications in oncologic and inflammatory disorders. It was therefore the aim of this study to develop a folate-derived Ga-68-based positron emission tomography (PET...
作者:Susanne Kossatz , Wolfgang A Weber , Thomas Reiner
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (1)DOAJ
摘要:Targeting and inhibiting DNA repair pathways is a powerful strategy of controlling malignant growth. One such strategy includes the inhibition of PARP1, a central element in the intracellular DNA damage response. To determine and visualize the expression and intercellular distrib...
作者:Thomas Reiner , Zahi A. Fayad ...
来源:[J].Journal of the American College of Cardiology(IF 14.086), 2018, Vol.71 (3), pp.321-335Elsevier
摘要:Abstract(#br)Background(#br)Oxidation-specific epitopes (OSEs) are proinflammatory, and elevated levels in plasma predict cardiovascular events.(#br)Objectives(#br)The purpose of this study was to develop novel positron emission tomography (PET) probes to noninvasively image OSE-...
作者:Thomas Reiner , Zahi A. Fayad ...
来源:[J].Journal of Controlled Release(IF 7.633), 2017, Vol.262, pp.47-57Elsevier
摘要:Abstract(#br)Atherosclerosis is a leading cause of worldwide morbidity and mortality whose management could benefit from novel targeted therapeutics. Nanoparticles are emerging as targeted drug delivery systems in chronic inflammatory disorders. To optimally exploit nanomedi...
作者:... Axel Vansteene , Jun Tang , Thomas Reiner
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2017, Vol.48, pp.9-15Elsevier
摘要:Abstract(#br)Rationale(#br)Ataxia telangiectasia and Rad3-related (ATR) threonine serine kinase is one of the key elements in orchestrating the DNA damage response (DDR). As such, inhibition of ATR can amplify the effects of chemo- and radiation-therapy, and several ATR inhi...
作者:Thomas Reiner , John T. Poirier
来源:[J].Journal of Thoracic Oncology(IF 4.473), 2019Elsevier
摘要:Abstract(#br)Introduction(#br)Inhibitors of poly-(ADP)-ribose polymerase (PARP) are promising therapeutics for SCLC. We tested whether PARP inhibitor (PARPi) target engagement as measured by a fluorine 18–radiolabeled PARPi ([ 18 F]PARPi) has the potential to predict drug ef...
作者:... Wolfgang A. Weber , Joel R. Garbow , Thomas Reiner
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-10Springer
摘要:Abstract(#br) Background(#br)Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, or complex image post-processing; desp...
作者:... Naga Vara Kishore Pillarsetty , Jason A. Konner , Thomas Reiner
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-10Springer
摘要:Abstract(#br) Background(#br)The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim ...
作者:... Paula Demétrio Souza , Geoff S. Higgins , Thomas Reiner
来源:[J].Molecular Imaging and Biology(IF 3.095), 2019, Vol.21 (4), pp.705-712Springer
摘要:Abstract(#br) Purpose(#br)Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) i...

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