全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Thomas R. Caulfield , Kotaro Ogaki ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. T...
作者:... Stephanie Hines , Paldeep S. Atwal , Thomas R. Caulfield
来源:[J].Medicina(IF 0.55), 2019, Vol.55 (5)DOAJ
摘要:Background and objectives: Loeys–Dietz syndrome 3, also known as aneurysms-–osteoarthritis syndrome, is an autosomal dominant genetic connective tissue disease caused by pathogenic variants in SMAD3 , a transcription factor involved in TGF-β signaling. This disorder is ...
作者:Thomas R. Caulfield , Elisabeth L. Moussaud‐Lamodière ...
来源:[J].Human Mutation(IF 5.213), 2015, Vol.36 (8), pp.774-786Wiley
摘要:ABSTRACT(#br)Mutations in the PARKIN/PARK2 gene that result in loss‐of‐function of the encoded, neuroprotective E3 ubiquitin ligase Parkin cause recessive, familial early‐onset Parkinson disease. As an increasing number of rare Parkin sequence variants with unclear path...
作者:Thomas R. Caulfield , Aneel Paulus ...
来源:[J].Chemical Biology & Drug Design(IF 2.469), 2015, Vol.86 (5), pp.1036-1048Wiley
摘要:The ubiquitin–proteasome system ( UPS ) is increasingly recognized as a therapeutic target for the development of anticancer therapies. The success of the 20S proteasome core particle (20S CP ) inhibitor bortezomib in the clinical management of multiple myeloma has raised th...
作者:Thomas R. Caulfield
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2011, Vol.29 (8), pp.1006-1014Elsevier
摘要:Abstract(#br)The double belt model for lipid-bound discoidal apolipoprotein A-I consists of two alpha-helical monomers bound about an unilamellar bilayer of lipids. Previous work, based on salt bridge calculations, has demonstrated that the L5/5 registration, Milano mutant, ...
作者:Thomas R. Caulfield , Rajendra K. Agrawal
来源:[J].Journal of Molecular Biology(IF 3.905), 2006, Vol.358 (1), pp.193-212Elsevier
摘要:Protein translation is essential for all forms of life and is conducted by a macromolecular complex, the ribosome. Evolutionary changes in protein and RNA sequences can affect the 3D organization of structural features in ribosomes in different species. The most dramatic cha...
作者:Thomas R. Caulfield , Alicia Hernández-Campos ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2011, Vol.46 (8), pp.3499-3508Elsevier
摘要:Abstract(#br)Trichomonosis is a common sexually transmitted infectious disease linked to reproductive health complications. Recently, the benzimidazole nucleus has emerged as a promising scaffold to develop new trichomonicidal agents. Despite the fact that large amounts of e...

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