全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jeffrey J. Lochhead , Patrick T. Ronaldson , Thomas P. Davis
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.910-920Springer
摘要:A functional blood-brain barrier (BBB) is necessary to maintain central nervous system (CNS) homeostasis. Many diseases affecting the CNS, however, alter the functional integrity of the BBB. It has been shown that various diseases and physiological stressors can impact the B...
作者:Wazir Abdullahi , Thomas P. Davis , Patrick T. Ronaldson
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.931-939Springer
摘要:Drug delivery to the central nervous system (CNS) is greatly limited by the blood-brain barrier (BBB). Physical and biochemical properties of the BBB have rendered treatment of CNS diseases, including those with a hypoxia/reoxygenation (H/R) component, extremely difficult. T...
作者:Charles P. Schaefer , Margaret E. Tome , Thomas P. Davis
来源:[J].Fluids and Barriers of the CNS, 2017, Vol.14 (1)Springer
摘要:Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on th...
作者:Thomas P. Davis , Feng Ding
来源:[J].Nano Research(IF 7.392), 2018, Vol.11 (7), pp.3636-3647Springer
摘要:Abstract(#br)Understanding how small molecules interface with amyloid fibrils at the nanoscale is of importance for developing therapeutic treatments against amyloid-based diseases. Here, we show for the first time that human islet amyloid polypeptides (IAPP) in the fibrillar for...
作者:Thomas P. Davis , Michael R. Whittaker
来源:[J].Journal of Controlled Release(IF 7.633), 2017, Vol.259, pp.83-91Elsevier
摘要:Abstract(#br)Colistin methanesulfonate (CMS) is the only prodrug of colistin available for clinical use for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Owing to its slow and variable release, an alternative is urgently required to impro...
作者:... Michael R. Whittaker , Thomas P. Davis , Ben J. Boyd
来源:[J].Journal of Colloid And Interface Science(IF 3.172), 2017, Vol.508, pp.517-524Elsevier
摘要:Abstract(#br)Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible ...
作者:... Pu Chun Ke , Thomas P. Davis , Kristian Kempe
来源:[J].European Polymer Journal(IF 2.562), 2017, Vol.88, pp.486-515Elsevier
摘要:Abstract(#br)Poly(2-oxazoline)s (POx) are a class of polymers with tremendous potential for biomedical applications. The straightforward access to side and main chain functionalities by selecting suitable monomers and initiators/terminating agents, respectively, in combination wi...
作者:... Ava Faridi , Thomas P. Davis , Pu Chun Ke
来源:[J].BBA - Biomembranes(IF 3.389), 2018Elsevier
摘要:Abstract(#br)Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of human diseases. The amyloid aggregation of human islet amyloid polypeptide (IAPP) and alpha synuclein (αS), specifically, is a hallmark of type 2 diabetes (T2D) and Parkinson's...

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